Spatial control over cell attachment by partial solvent entrapment of poly lysine in microfluidic channels.

Spatial control over cell attachment by partial solvent entrapment of poly lysine in microfluidic channels. Research Abstract Details 

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Spatial control over cell attachment by partial solvent entrapment of poly lysine in microfluidic channels. Abstract Text:

Nicki K Baman,Galen B Schneider,Treniece L Terry,Rebecca Zaharias,Aliasger K Salem,

We demonstrate spatial control over cell attachment on biodegradable surfaces by flowing cell adhesive poly (D-lysine) (PDL) in a trifluoroethanol (TFE)-water mixture through microfluidic channels placed on a biodegradable poly (lactic acid)-poly (ethylene glycol) (PLA-PEG) substrate. The partial solvent mixture swells the PLA-PEG within the confines of the microfluidic channels allowing PDL to diffuse on to the surface gel layer. When excess water is flowed through the channels substituting the TFE-water mixture, the swollen PLA surface collapses, entrapping PDL polymer. Results using preosteoblast human palatal mesenchymal cells (HEPM) indicate that this new procedure can be used for facile attachment of cells in localized regions. The PEG component of the PLA-PEG copolymer prevents cells from binding to the nonpatterned regions.

Spatial control over cell attachment by partial solvent entrapment of poly lysine in microfluidic channels. Publishing Authors By Initials

NK Baman,GB Schneider,TL Terry,R Zaharias,AK Salem,

For similar investigative techniques: clinical laboratory techniques: culture techniques: tissue engineering research abstracts see: investigative techniques: clinical laboratory techniques: culture techniques: tissue engineering research

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MEDLINE DATE:

Spatial control over cell attachment by partial solvent entrapment of poly lysine in microfluidic channels. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: International journal of nanomedicine

VOLUME: 1

Page Numbers: 213-7

Journal Abbreviation:

ISSN: 1176-9114

DAY: 3

MONTH: 12

YEAR: 2006

Spatial control over cell attachment by partial solvent entrapment of poly lysine in microfluidic channels. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 101263847

Spatial control over cell attachment by partial solvent entrapment of poly lysine in microfluidic channels. Keywords Mesh Terms:

KEYWORDS: Tissue Engineering

MESH TERMS: methods

Chemical & Substance for Abstract: Spatial control over cell attachment by partial solvent entrapment of poly lysine in microfluidic channels. Information

Substance Name: Polylysine

Registry Number: 25104-18-1

Grant and Affiliation Information for Spatial control over cell attachment by partial solvent entrapment of poly lysine in microfluidic channels.

AFFILIATION: Department of Biomedical Engineering, College of Engineering, University of Iowa, Iowa City, IA, USA.

Country: New Zealand

AGENCY: United States NCI

GRANT: P50 CA097274-04

ACRONYM: CA

MEDLINETA: Int J Nanomedicine

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