Sparse and selective odor coding by mitral/tufted neurons in the main olfactory bulb.

Sparse and selective odor coding by mitral/tufted neurons in the main olfactory bulb. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Sparse and selective odor coding by mitral/tufted neurons in the main olfactory bulb. Abstract Text:

Ian G Davison,Lawrence C Katz,

The mammalian olfactory system recognizes an enormous variety of odorants carrying a wide range of important behavioral cues. In the main olfactory bulb (MOB), odorants are ultimately represented through the action potential activity of mitral/tufted cells (M/Ts), whose selectivity and tuning to odorant molecules are therefore fundamental determinants of MOB sensory coding. However, the sheer number and diversity of discrete olfactory stimuli has been a major barrier to comprehensively evaluating M/T selectivity. To address this issue, we assessed M/T odorant responses in anesthetized mice to a 348-odorant panel widely and systematically distributed throughout chemical space, presented both individually and in mixtures at behaviorally relevant concentrations. We found that M/T activation by odorants was markedly selective, with neurons responding robustly, sensitively, and reliably to only a highly restricted subset of stimuli. Multiple odorants activating a single neuron commonly shared clear structural similarity, but M/T tuning also frequently extended beyond obviously defined chemical categories. Cells typically responded to effective compounds presented both individually and in mixtures, although firing rates evoked by mixtures typically showed partial suppression. Response selectivity was further confirmed in awake animals by chronic recordings of M/Ts. These data indicate that individual M/Ts encode specific odorant attributes shared by only a small fraction of compounds and imply that the MOB relays the collective molecular features of an odorant stimulus through a restricted set of M/Ts, each narrowly tuned to a particular stimulus characteristic.

Sparse and selective odor coding by mitral/tufted neurons in the main olfactory bulb. Publishing Authors By Initials

IG Davison,LC Katz,

For similar sensation: smell research abstracts see: sensation: smell research

PUBMED ID PMID:

MEDLINE DATE:

Sparse and selective odor coding by mitral/tufted neurons in the main olfactory bulb. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The Journal of neuroscience : the official journal

VOLUME: 27

Page Numbers: 2091-101

Journal Abbreviation: J. Neurosci.

ISSN: 1529-2401

DAY: 21

MONTH: Feb

YEAR: 2007

Sparse and selective odor coding by mitral/tufted neurons in the main olfactory bulb. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8102140

Sparse and selective odor coding by mitral/tufted neurons in the main olfactory bulb. Keywords Mesh Terms:

KEYWORDS: Smell

MESH TERMS: physiology

Chemical & Substance for Abstract: Sparse and selective odor coding by mitral/tufted neurons in the main olfactory bulb. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Sparse and selective odor coding by mitral/tufted neurons in the main olfactory bulb.

AFFILIATION: Howard Hughes Medical Institute and Department of Neurobiology, Duke University Medical Center, Durham, North Carolina 27710, USA. davison@neuro.duke.edu

Country: United States

AGENCY: United States NIDCD

GRANT: R01 DC005671

ACRONYM: DC

MEDLINETA: J Neurosci

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Sparse and selective odor coding by mitral/tufted neurons in the main olfactory bulb Related Publications

• A distributed computing tool for generating neural simulation databases.
• Attempted suicide among transgender persons: The influence of gender-based discrimination and victimization.
• Biophysical analysis of prototype microbicidal gels.
• Cognitive control and prehospital endotracheal intubation.
• Comparison between morphological and staining characteristics of live and dead eggs of Schistosoma mansoni.
• Correlates of referral practices of general surgeons to plastic surgeons for mastectomy reconstruction.
• Direct observation of computer workplace risk factors of college students.
• Elevation of glucocorticoids is necessary but not sufficient for the escalation of cocaine self-administration by chronic electric footshock stress in rats.
• Genome diversity in microbial eukaryotes.
• Impediment profiling for smoking cessation: application in the worksite.
• Information given to postmenopausal women on coronary computed tomography may influence cardiac risk reduction efforts.
• Interpreting properties of microbicide drug delivery gels: analyzing deployment kinetics due to squeezing.
• Krüppel-like factor 5 activates MEK/ERK signaling via EGFR in primary squamous epithelial cells.
• Massage therapy for osteoarthritis of the knee: a randomized controlled trial.
• Motor innervation of the muscle spindle: the contribution of bernhard katz.
• Neighborhoods matter: use of hospitals with worse outcomes following total knee replacement by patients from vulnerable populations.
• Ocular phenotype in a mouse gene knockout model for infantile neuronal ceroid lipofuscinosis.
• Orthopaedic procedure volume and patient outcomes: a systematic literature review.
• Overexpression of Kruppel-like factor 5 in esophageal epithelia in vivo leads to increased proliferation in basal but not suprabasal cells.
• Plasma cathepsin D isoforms and their active metabolites increase after myocardial infarction and contribute to plasma renin activity.
• Role of membrane potential in calcium signaling during rhythmic bursting in tritonia swim interneurons.
• Short- and long-term response to and weaning from infliximab therapy in pediatric ulcerative colitis.
• Sparse and selective odor coding by mitral/tufted neurons in the main olfactory bulb.
• State-dependent modulation of time-varying gustatory responses.
• Synaptic integration of olfactory information in mouse anterior olfactory nucleus.
• Temporary basolateral amygdala lesions disrupt acquisition of socially transmitted food preferences in rats.
• The influence of race, ethnicity, and individual socioeconomic factors on breast cancer stage at diagnosis.
• The many flavors of temporal coding in gustatory cortex.
• Undergraduate college students' upper extremity symptoms and functional limitations related to computer use: a replication study.
• Understanding HSV-1 entry glycoproteins.