Soybean saponin inhibits tumor cell metastasis by modulating expressions of MMP-2, MMP-9 and TIMP- 2.

Soybean saponin inhibits tumor cell metastasis by modulating expressions of MMP-2, MMP-9 and TIMP- 2. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Soybean saponin inhibits tumor cell metastasis by modulating expressions of MMP-2, MMP-9 and TIMP- 2. Abstract Text:

Ji-Hye Kang,In-Hee Han,Mi-Kyung Sung,Hoon Yoo,Young-Gyun Kim,Jeong-Sang Kim,Teruo Kawada,Rina Yu,Ji-Hye Kang,In-Hee Han,Mi-Kyung Sung,Hoon Yoo,Young-Gyun Kim,Jeong-Sang Kim,Teruo Kawada,Rina Yu,

The antimetastatic properties of soybean saponin were investigated by evaluating matrix metalloproteinase (MMP-2 and MMP-9) production in HT-1080 cells. The mRNA expression levels of MMP-2 and MMP-9 were determined by RT-PCR analysis. The levels of secreted MMP-2, MMP-9 and tissue inhibitor of metalloproteinase-2 (TIMP-2) were determined by gelatin zymography and/or ELISA. The invasion of a Matrigel-coated membrane by human fibrosarcoma HT-1080 and HT-29 colon cancer cells was quantitatively assessed by counting the migrated cells. The treatment of HT-1080 cells with soybean saponin inhibited the mRNA expression of and reduced the amounts of secreted MMP-2 and MMP-9, whereas it increased the amount of secreted TIMP-2 dose-dependently. Soybean saponin significantly inhibited the invasion of HT-1080 cells through a Matrigel-coated membrane. The antimetastatic properties by soybean saponin were further confirmed by in vivo mice experiment via the tail vein injection of CT-26 colon cancer cells after feeding the mice the dietary soybean saponin. The incidence of metastatic tumor colonization of lungs of mice moderately decreased 2 weeks after the tail vein injection of CT-26 cells. Our current data support the notion that soybean saponin inhibits tumor cell metastasis by suppressing MMP-2 and MMP-9 productions, and stimulating TIMP-2 secretion, thereby suggesting that soybean saponin has a chemopreventive property against cancer metastasis.

Soybean saponin inhibits tumor cell metastasis by modulating expressions of MMP-2, MMP-9 and TIMP- 2. Publishing Authors By Initials

JH Kang,IH Han,MK Sung,H Yoo,YG Kim,JS Kim,T Kawada,R Yu,JH Kang,IH Han,MK Sung,H Yoo,YG Kim,JS Kim,T Kawada,R Yu,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Soybean saponin inhibits tumor cell metastasis by modulating expressions of MMP-2, MMP-9 and TIMP- 2. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Cancer letters

VOLUME: 261

Page Numbers: 84-92

Journal Abbreviation: Cancer Lett.

ISSN: 0304-3835

DAY: 20

MONTH: 12

YEAR: 2007

Soybean saponin inhibits tumor cell metastasis by modulating expressions of MMP-2, MMP-9 and TIMP- 2. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7600053

Soybean saponin inhibits tumor cell metastasis by modulating expressions of MMP-2, MMP-9 and TIMP- 2. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Soybean saponin inhibits tumor cell metastasis by modulating expressions of MMP-2, MMP-9 and TIMP- 2. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Soybean saponin inhibits tumor cell metastasis by modulating expressions of MMP-2, MMP-9 and TIMP- 2.

AFFILIATION: Department of Food Science and Nutrition, University of Ulsan, Mugeo-dong, Nam-ku, Ulsan 680-749, Republic of Korea.

Country: Ireland

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Cancer Lett

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Soybean saponin inhibits tumor cell metastasis by modulating expressions of MMP-2, MMP-9 and TIMP- 2 Related Publications

• An overview of vagal airway receptors.
• Element mixing distribution and structure feature of fusion zone in laser welding between different alloys and pure titanium.
• Endothelial function and carotid artery wall thickening in patients with early essential hypertension.
• Genetic factors underlying prostate cancer.
• Genotype-phenotype analysis for the polymorphic CA repeat in the insulin-like growth factor-I (IGF-I) gene.
• Na(+)/K(+) -ATPase as a marker for detecting pulmonary sensory receptors.
• RRR-alpha-tocopheryl succinate inhibits human gastric cancer SGC-7901 cell growth by inducing apoptosis and DNA synthesis arrest.
• The effects of vitamin E succinate on the expression of c-jun gene and protein in human gastric cancer SGC-7901 cells.
• [A case of sepsis and multiple organ dysfunction syndrome complicated by Staphylococcus infection]
• [Anisodamine in prevention and treatment of sepsis of severely burned patients]
• [Association study on HLA-DP and -DQ allelic polymorphisms and nasopharyngeal carcinoma in the Han nationality in Hunan province]
• [Change of catecholamine in serum and hippocampus of rats after electromagnetic irradiation and the selection of protective site]
• [Changes of phosphorylation states of Cx43 protein in Chinese hamster lung cells induced by SiO2]
• [Double uterus and hydatidiform mole in the malformed uterus: report of one case]
• [Early diagnosis of pancreatic cancer is essential to improving the effect of treatment]
• [Effect of oxidated low-density lipoprotein on early apoptosis of vascular smooth muscle cell]
• [Extinguishment of harmful algae by organo-clay]
• [Humoral immune response in mice to hybrid nucleic acid vaccines containing Plasmodium falciparum merozoite surface protein 1 block 17-based gene]
• [PCR in detecting the correlation between infection of HBV and cholelithiasis]
• [Post-mastectomy radiotherapy with different fractionated dose schemes in early breast cancer]
• [Primary extranodal lymphomas: analyses of clinical characteristics and misdiagnoses of 139 cases]
• [Relationship between Helicobacter pylori infection and expression of c-myc, Bcl-2, and Bax protein in different gastric mucosa lesions]
• [Researches in forensic biomechanics]
• [Study on antitumor effect and mechanism of aloe polysaccharides]
• [Study on the genic polymorphism of HLA-DRB1 in a population in the north of China]
• [The effect of radix Pseudostellariae from 8 habitats on spleen-deficiency and immunologic function]
• [The expression and activity of caspase-8 in the process of vitamin E succinate-induced apoptosis in human gastric carcinoma SGC-7901 cells]
• [Treatment of burns combined injury]
• [Wavelet feature extraction and classification of Doppler ultrasound blood flow signals]
• [p15 gene expression in acute lymphoblastic leukemia cell line Molt4 induced by arsenic trioxide]