Soy isoflavones do not affect bone resorption in postmenopausal women: a dose-response study using a novel approach with 41Ca.

Soy isoflavones do not affect bone resorption in postmenopausal women: a dose-response study using a novel approach with 41Ca. Research Abstract Details 

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Soy isoflavones do not affect bone resorption in postmenopausal women: a dose-response study using a novel approach with 41Ca. Abstract Text:

J M K Cheong,B R Martin,G S Jackson,D Elmore,G P McCabe,J R Nolan,S Barnes,M Peacock,C M Weaver,

INTRODUCTION: The purpose of this 3-way crossover study was to identify the effective dose of soy protein isolate enriched with isoflavones for suppressing bone resorption in postmenopausal women using a novel, rapid assessment of antibone resorbing treatments. METHODS: Thirteen postmenopausal women (>or=6 yr since menopause) were predosed with 41Ca iv. After a 200-d baseline period, subjects were given 43 g soy protein/d that contained 0, 97.5, or 135.5 mg total isoflavones in randomized order. The soy protein isolate powder was incorporated into baked products and beverages. Each 50-d intervention phase was preceded by a 50-d pretreatment phase for comparison. Serum isoflavone levels and biochemical markers were measured at the end of each phase. Twenty-four-hour urine samples were collected approximately every 10 d during each phase for 41Ca/Ca analysis by accelerator mass spectrometry. RESULTS: Serum isoflavone levels reflected the amount of isoflavones consumed in a dose-dependent manner. None of the isoflavone levels had a significant effect on biochemical markers of bone turnover, urinary cross-linked N teleopeptides of type I collagen and serum osteocalcin, or bone turnover as assessed by urinary 41Ca/Ca ratios. CONCLUSIONS: Soy protein with isoflavone doses of up to 135.5 mg/d did not suppress bone resorption in postmenopausal women. This is the first efficacy trial using the novel technique of urinary 41Ca excretion from prelabeled bone.

Soy isoflavones do not affect bone resorption in postmenopausal women: a dose-response study using a novel approach with 41Ca. Publishing Authors By Initials

JM Cheong,BR Martin,GS Jackson,D Elmore,GP McCabe,JR Nolan,S Barnes,M Peacock,CM Weaver,

For similar proteins: plant proteins: soybean proteins research abstracts see: proteins: plant proteins: soybean proteins research

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Soy isoflavones do not affect bone resorption in postmenopausal women: a dose-response study using a novel approach with 41Ca. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: The Journal of clinical endocrinology and metaboli

VOLUME: 92

Page Numbers: 577-82

Journal Abbreviation: J. Clin. Endocrinol. Metab.

ISSN: 0021-972X

DAY: 5

MONTH: 12

YEAR: 2006

Soy isoflavones do not affect bone resorption in postmenopausal women: a dose-response study using a novel approach with 41Ca. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 375362

Soy isoflavones do not affect bone resorption in postmenopausal women: a dose-response study using a novel approach with 41Ca. Keywords Mesh Terms:

KEYWORDS: Soybean Proteins

MESH TERMS: administration & dosage

Chemical & Substance for Abstract: Soy isoflavones do not affect bone resorption in postmenopausal women: a dose-response study using a novel approach with 41Ca. Information

Substance Name: Calcium

Registry Number: 7440-70-2

Grant and Affiliation Information for Soy isoflavones do not affect bone resorption in postmenopausal women: a dose-response study using a novel approach with 41Ca.

AFFILIATION: Foods and Nutrition, Purdue University, 700 West State Street, West Lafayette, Indiana 47907-2059, USA.

Country: United States

AGENCY: United States NCCAM

GRANT: P50 AT00477

ACRONYM: AT

MEDLINETA: J Clin Endocrinol Metab

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