Sox2 is required for development of taste bud sensory cells.

Sox2 is required for development of taste bud sensory cells. Research Abstract Details 

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Sox2 is required for development of taste bud sensory cells. Abstract Text:

Tadashi Okubo,Larysa H Pevny,Brigid L M Hogan,Tadashi Okubo,Larysa H Pevny,Brigid L M Hogan,

Sox2 is expressed in basal epithelial cells of the tongue, with high levels in taste bud placodes, fungiform papillae, and mature taste cells, and low levels in filiform papillae. High Sox2 expression appears to lie downstream from canonical Wnt signaling. In hypomorphic Sox2(EGFP/LP) embryos, placodes form but no mature taste buds develop. In contrast, transgenic overexpression of Sox2 in the basal cells inhibits differentiation of filiform keratinocytes. Together, our loss-of-function and gain-of-function studies suggest that Sox2 functions in a dose-dependent manner to regulate the differentiation of endodermal progenitor cells of the tongue into taste bud sensory cells versus keratinocytes.

Sox2 is required for development of taste bud sensory cells. Publishing Authors By Initials

T Okubo,LH Pevny,BL Hogan,T Okubo,LH Pevny,BL Hogan,

For similar peptides: intercellular signaling peptides and proteins: wnt proteins research abstracts see: peptides: intercellular signaling peptides and proteins: wnt proteins research

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Sox2 is required for development of taste bud sensory cells. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Genes & development

VOLUME: 20

Page Numbers: 2654-9

Journal Abbreviation: Genes Dev.

ISSN: 0890-9369

DAY: 1

MONTH: Oct

YEAR: 2006

Sox2 is required for development of taste bud sensory cells. Information

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LANGUAGE: eng

NlmUniqueID: 8711660

Sox2 is required for development of taste bud sensory cells. Keywords Mesh Terms:

KEYWORDS: Wnt Proteins

MESH TERMS: metabolism

Chemical & Substance for Abstract: Sox2 is required for development of taste bud sensory cells. Information

Substance Name: Wnt Proteins

Registry Number: 0

Grant and Affiliation Information for Sox2 is required for development of taste bud sensory cells.

AFFILIATION: Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA. t.okubo@nibb.ac.jp

Country: United States

AGENCY: United States NHLBI

GRANT: HL071303

ACRONYM: HL

MEDLINETA: Genes Dev

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