Sources and biology of regulatory factors active on mouse myeloid leukemic cells.

Sources and biology of regulatory factors active on mouse myeloid leukemic cells. Research Abstract Details 

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Sources and biology of regulatory factors active on mouse myeloid leukemic cells. Abstract Text:

D Metcalf,

The action of serum or cells in enforcing differentiation in mouse myelomonocytic leukemic cells was monitored in agar cultures of WEHI-3B leukemic cells. The repeated intravenous injection of 5 micrograms endotoxin initially increased serum differentiating activity but after the third injection responses to further injections decreased markedly. Congenitally athymic (nude) mice exhibited normal rises in serum differentiating activity when injected with endotoxin but C3H HeJ mice failed to respond to challenge with purified lipid A. Whole body irradiation up to 1,200 rads did not increase serum differentiating activity but did not suppress responses to challenge injection of endotoxin. Coculture of WEHI-3B cells with peritoneal cells from normal or irradiated BALB/c mice caused marked granulocytic differentiation in WEHI-3B colonies. This effect was not seen if leukemic cells were cultured with thymus, spleen, or bone marrow cells. The serum halflife of the factor in postendotoxin serum enforcing differentiation of WEHI-3B cells was shown to be 1.5-2.3 hr.

Sources and biology of regulatory factors active on mouse myeloid leukemic cells. Publishing Authors By Initials

D Metcalf,

For similar therapeutics: radiotherapy: whole-body irradiation research abstracts see: therapeutics: radiotherapy: whole-body irradiation research

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Sources and biology of regulatory factors active on mouse myeloid leukemic cells. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Journal of cellular physiology. Supplement

VOLUME: 1

Page Numbers: 175-83

Journal Abbreviation:

ISSN: 0737-1462

DAY: 12

MONTH: 02

YEAR: 1982

Sources and biology of regulatory factors active on mouse myeloid leukemic cells. Information

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LANGUAGE: eng

NlmUniqueID: 8300145

Sources and biology of regulatory factors active on mouse myeloid leukemic cells. Keywords Mesh Terms:

KEYWORDS: Whole-Body Irradiation

MESH TERMS: physiology

Chemical & Substance for Abstract: Sources and biology of regulatory factors active on mouse myeloid leukemic cells. Information

Substance Name: Endotoxins

Registry Number: 0

Grant and Affiliation Information for Sources and biology of regulatory factors active on mouse myeloid leukemic cells.

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Country: UNITED STATES

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MEDLINETA: J Cell Physiol Suppl

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