Some characteristics of hydrogen- and alkylhydroperoxides metabolizing systems in cardiac tissue.

Some characteristics of hydrogen- and alkylhydroperoxides metabolizing systems in cardiac tissue. Research Abstract Details 

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Some characteristics of hydrogen- and alkylhydroperoxides metabolizing systems in cardiac tissue. Abstract Text:

M Tamura,N Oshino,B Chance,

The effect of hydroperoxides on the cardiac tissue was studied by using hemoglobin-free perfused rat heart. Ethylhydroperoxide was degraded mainly through the glutathione peroxidase system of the heart at a maximal rate of about 1.2 mumol/min per g wet wt. When ethylhydroperoxide infused was not degraded completely, the hydroperoxide concentration in the effluent perfusate paralleled the formation of ferrylmyoglobin in the heart. The infusion of ethylhydroperoxide caused release of oxidized glutathione into the effluent perfusate as a result of the enhancement of the cytosolic glutathione peroxidase reaction. The leakage of oxidized glutathione reached the maximal rate of 3.5 nmol/min per g wet wt with the infusion of 175 microM ethylhydroperoxide. At hydroperoxide concentrations above 150 microM, oxidations of pyridine nucleotides and of cytochrome a + a3 occurred, probably through a stimulation of the mitochondrial glutathione peroxidase reaction, and resulted in sudden failure of the heart function. The infusion of t-butyl- and cumene-hydroperoxides, which are unable to react with myoglobin, also caused the oxidations of pyridine nucleotides and cytochrome a + a3, the inhibition of oxygen consumption and the failure of heart function. The results indicate that the cardiac toxicity of hydroperoxides is due mainly to their effect on mitochondrial metabolism.

Some characteristics of hydrogen- and alkylhydroperoxides metabolizing systems in cardiac tissue. Publishing Authors By Initials

M Tamura,N Oshino,B Chance,

For similar animals: animal population groups: animals, inbred strains: rats, inbred strains research abstracts see: animals: animal population groups: animals, inbred strains: rats, inbred strains research

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Some characteristics of hydrogen- and alkylhydroperoxides metabolizing systems in cardiac tissue. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Journal of biochemistry

VOLUME: 92

Page Numbers: 1019-31

Journal Abbreviation: J. Biochem.

ISSN: 0021-924X

DAY: 19

MONTH: Oct

YEAR: 1982

Some characteristics of hydrogen- and alkylhydroperoxides metabolizing systems in cardiac tissue. Information

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LANGUAGE: eng

NlmUniqueID: 376600

Some characteristics of hydrogen- and alkylhydroperoxides metabolizing systems in cardiac tissue. Keywords Mesh Terms:

KEYWORDS: Rats, Inbred Strains

MESH TERMS: pharmacology

Chemical & Substance for Abstract: Some characteristics of hydrogen- and alkylhydroperoxides metabolizing systems in cardiac tissue. Information

Substance Name: Glutathione Peroxidase

Registry Number: EC 1.11.1.9

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Country: JAPAN

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MEDLINETA: J Biochem

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