Some aspects of antioxidant status in blood from alcoholics.

Some aspects of antioxidant status in blood from alcoholics. Research Abstract Details 

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Some aspects of antioxidant status in blood from alcoholics. Abstract Text:

G E ,J Johnsen,A ,S L Marklund,N Skylv,A ,J E Bache-Wiig,J ,C A Drevon,

The effect of ethanol consumption on serum concentration of alpha-tocopherol, erythrocyte activities of superoxide dismutase, glutathione peroxidase, and catalase were studied in 34 male alcoholics and 35 age-matched controls. Serum concentration of alpha-tocopherol was 30% lower in the alcoholics as compared to the controls (p less than 0.001). No significant difference was found in erythrocyte activities of Cu-Zn-containing superoxide dismutase, glutathione peroxidase, or catalase between the groups. Of the 12 alcoholics with subnormal serum alpha-tocopherol, 50% had concomitant neurological clinical scores and cerebellar atrophy, and their neurological scores were significantly higher (82%) than for alcoholics with normal alpha-tocopherol levels (p less than 0.03). However, no significant correlation was observed between levels of alpha-tocopherol and neurological clinical scores or cerebellar atrophy. When entering the study, alcoholics and controls were each randomized into two separate groups, receiving vitamin E supplementation (100 mg/day) or placebo capsules for 10 days, respectively. In the four subgroups, alpha-tocopherol levels increased only in alcoholics receiving vitamin E supplementation (23%) (p less than 0.001). The reduced serum levels of alpha-tocopherol in alcoholics may be normalized by vitamin E supplementation.

Some aspects of antioxidant status in blood from alcoholics. Publishing Authors By Initials

GE ,J Johnsen,A ,SL Marklund,N Skylv,A ,JE Bache-Wiig,J ,CA Drevon,

For similar heterocyclic compounds: heterocyclic compounds, 2-ring: benzopyrans: vitamin e: tocopherols: alpha-tocopherol research abstracts see: heterocyclic compounds: heterocyclic compounds, 2-ring: benzopyrans: vitamin e: tocopherols: alpha-tocopherol research

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Some aspects of antioxidant status in blood from alcoholics. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Alcoholism, clinical and experimental research

VOLUME: 12

Page Numbers: 806-10

Journal Abbreviation: Alcohol. Clin. Exp. Res.

ISSN: 0145-6008

DAY: 19

MONTH: Dec

YEAR: 1988

Some aspects of antioxidant status in blood from alcoholics. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7707242

Some aspects of antioxidant status in blood from alcoholics. Keywords Mesh Terms:

KEYWORDS: alpha-Tocopherol

MESH TERMS: analogs & derivatives

Chemical & Substance for Abstract: Some aspects of antioxidant status in blood from alcoholics. Information

Substance Name: Superoxide Dismutase

Registry Number: EC 1.15.1.1

Grant and Affiliation Information for Some aspects of antioxidant status in blood from alcoholics.

AFFILIATION: National Institute of Forensic Toxicology, Oslo, Norway.

Country: UNITED STATES

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MEDLINETA: Alcohol Clin Exp Res

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