Somatic cell and sperm cell cytogenetics in a patient with t(14; 21).

Somatic cell and sperm cell cytogenetics in a patient with t(14; 21). Research Abstract Details 

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Somatic cell and sperm cell cytogenetics in a patient with t(14; 21). Abstract Text:

Yan-Ping Tang,Xiu-Sheng Liu,Yuan Liu,Zhen-Rong Yang,Yan Chen,Cheng-Liang Xiong,

Approximately 15%-20% of clinically recognizable pregnancies end in spontaneous abortion. About half of the spontaneous abortions in the early stage of the pregnancy are due to chromosomal abnormalities. Using GTG chromosome banding and dual-color fluorescence in situ hybridization (FISH) techniques, we determined the cytogenetic aberration in the husband of a couple with spontaneous recurrent abortions. Karyotype analysis showed 46, XX in the wife and 45, XY, -14, -21, +t(14; 21) in the husband. We studied the mechanism of formation of the abnormal chromosome with Robertsonian translocation between chromosomes 14 and 21 by FISH and flow cytometric sorting in the sperm cells. The result showed that 71% of the gametes were balanced and the remaining 29% were not. As a result, the couple was given genetic counseling.

Somatic cell and sperm cell cytogenetics in a patient with t(14; 21). Publishing Authors By Initials

YP Tang,XS Liu,Y Liu,ZR Yang,Y Chen,CL Xiong,

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Somatic cell and sperm cell cytogenetics in a patient with t(14; 21). Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Yi chuan xue bao = Acta genetica Sinica

VOLUME: 33

Page Numbers: 488-94

Journal Abbreviation: Yi Chuan Xue Bao

ISSN: 0379-4172

DAY: 27

MONTH: Jun

YEAR: 2006

Somatic cell and sperm cell cytogenetics in a patient with t(14; 21). Information

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LANGUAGE: eng

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AFFILIATION: Center for Reproductive Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Country: China

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MEDLINETA: Yi Chuan Xue Bao

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