Solvent-mediated proton transfer in catalysis by carbonic anhydrase.

Solvent-mediated proton transfer in catalysis by carbonic anhydrase. Research Abstract Details 

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Solvent-mediated proton transfer in catalysis by carbonic anhydrase. Abstract Text:

David N Silverman,Robert McKenna,

Considerable attention has been focused on proton transfer through intervening water molecules in complex macromolecules of biological interest, such as bacteriorhodopsin, cytochrome c oxidase, and many others. Proton transfer in catalysis by carbonic anhydrase provides a useful model for the study of the properties of such proton translocations. High-resolution X-ray crystallography in combination with measurements of catalysis have revealed new details of this process. A prominent proton shuttle residue His64 shows evidence of structural mobility, which appears to enhance proton transfer between the active site and bulk solvent. Moreover, the properties of the imidazole side chain of His64, including its conformations and pK(a), are finely tuned by surrounding residues of the active-site cavity. The structure of a network of ordered solvent molecules located between His64 and the active site are also sensitive to surrounding residues. These features combine to provide efficient proton-transfer rates as great as 10(6) s(-1) necessary to sustain rapid catalysis.

Solvent-mediated proton transfer in catalysis by carbonic anhydrase. Publishing Authors By Initials

DN Silverman,R McKenna,

For similar chemical actions and uses: specialty uses of chemicals: solvents research abstracts see: chemical actions and uses: specialty uses of chemicals: solvents research

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Solvent-mediated proton transfer in catalysis by carbonic anhydrase. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Accounts of chemical research

VOLUME: 40

Page Numbers: 669-75

Journal Abbreviation: Acc. Chem. Res.

ISSN: 0001-4842

DAY: 6

MONTH: 06

YEAR: 2007

Solvent-mediated proton transfer in catalysis by carbonic anhydrase. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 157313

Solvent-mediated proton transfer in catalysis by carbonic anhydrase. Keywords Mesh Terms:

KEYWORDS: Solvents

MESH TERMS: chemistry

Chemical & Substance for Abstract: Solvent-mediated proton transfer in catalysis by carbonic anhydrase. Information

Substance Name: Carbonic Anhydrase II

Registry Number: EC 4.2.1.-

Grant and Affiliation Information for Solvent-mediated proton transfer in catalysis by carbonic anhydrase.

AFFILIATION: Department of Pharmacology and Therapeutics, University of Florida College of Medicine, Gainesville, Florida 32610, USA. silvermn@college.med.ufl.edu

Country: United States

AGENCY: United States NIGMS

GRANT: GM25154

ACRONYM: GM

MEDLINETA: Acc Chem Res

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