Solution structure of stem-loop alpha of the hepatitis B virus post-transcriptional regulatory element.

Solution structure of stem-loop alpha of the hepatitis B virus post-transcriptional regulatory element. Research Abstract Details 

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Solution structure of stem-loop alpha of the hepatitis B virus post-transcriptional regulatory element. Abstract Text:

Martin Schwalbe,Oliver ,Aliaksandr Marchanka,Ramadurai Ramachandran,Sabine ,Tilman Heise,Matthias ,

Chronic hepatitis B virus (HBV) infections may lead to severe diseases like liver cirrhosis or hepatocellular carcinoma (HCC). The HBV post-transcriptional regulatory element (HPRE) facilitates the nuclear export of unspliced viral mRNAs, contains a splicing regulatory element and resides in the 3'-region of all viral transcripts. The HPRE consists of three sub-elements alpha (nucleotides 1151-1346), beta1 (nucleotides 1347-1457) and beta2 (nucleotides 1458-1582), which confer together full export competence. Here, we present the NMR solution structure (pdb 2JYM) of the stem-loop alpha (SLalpha, nucleotides 1292-1321) located in the sub-element alpha. The SLalpha contains a CAGGC pentaloop highly conserved in hepatoviruses, which essentially adopts a CUNG-like tetraloop conformation. Furthermore, the SLalpha harbours a single bulged G residue flanked by A-helical regions. The structure is highly suggestive of serving two functions in the context of export of unspliced viral RNA: binding sterile alpha motif (SAM-) domain containing proteins and/or preventing the utilization of a 3'-splice site contained within SLalpha.

Solution structure of stem-loop alpha of the hepatitis B virus post-transcriptional regulatory element. Publishing Authors By Initials

M Schwalbe,O ,A Marchanka,R Ramachandran,S ,T Heise,M ,

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Solution structure of stem-loop alpha of the hepatitis B virus post-transcriptional regulatory element. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Nucleic acids research

VOLUME: 36

Page Numbers: 1681-9

Journal Abbreviation: Nucleic Acids Res.

ISSN: 1362-4962

DAY: 7

MONTH: 02

YEAR: 2008

Solution structure of stem-loop alpha of the hepatitis B virus post-transcriptional regulatory element. Information

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LANGUAGE: eng

NlmUniqueID: 411011

Solution structure of stem-loop alpha of the hepatitis B virus post-transcriptional regulatory element. Keywords Mesh Terms:

KEYWORDS: Solutions

MESH TERMS: metabolism

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Substance Name: Solutions

Registry Number: 0

Grant and Affiliation Information for Solution structure of stem-loop alpha of the hepatitis B virus post-transcriptional regulatory element.

AFFILIATION: Leibniz-Institut für Altersforschung/Fritz-Lipmann-Institut, Beutenbergstr. 11, D-07745 Jena, Germany.

Country: England

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MEDLINETA: Nucleic Acids Res

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