Solution structure of HI1506, a novel two-domain protein from Haemophilus influenzae.

Solution structure of HI1506, a novel two-domain protein from Haemophilus influenzae. Research Abstract Details 

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Solution structure of HI1506, a novel two-domain protein from Haemophilus influenzae. Abstract Text:

Nese Sari,Yanan He,Victoria Doseeva,Karen Surabian,Jayanthi Ramprakash,Fred Schwarz,Osnat Herzberg,John Orban,

HI1506 is a 128-residue hypothetical protein of unknown function from Haemophilus influenzae. It was originally annotated as a shorter 85-residue protein, but a more detailed sequence analysis conducted in our laboratory revealed that the full-length protein has an additional 43 residues on the C terminus, corresponding with a region initially ascribed to HI1507. As part of a larger effort to understand the functions of hypothetical proteins from Gram-negative bacteria, and H. influenzae in particular, we report here the three-dimensional solution NMR structure for the corrected full-length HI1506 protein. The structure consists of two well-defined domains, an alpha/beta 50-residue N-domain and a 3-alpha 32-residue C-domain, separated by an unstructured 30-residue linker. Both domains have positively charged surface patches and weak structural homology with folds that are associated with RNA binding, suggesting a possible functional role in binding distal nucleic acid sites.

Solution structure of HI1506, a novel two-domain protein from Haemophilus influenzae. Publishing Authors By Initials

N Sari,Y He,V Doseeva,K Surabian,J Ramprakash,F Schwarz,O Herzberg,J Orban,

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MEDLINE DATE:

Solution structure of HI1506, a novel two-domain protein from Haemophilus influenzae. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Protein science : a publication of the Protein Soc

VOLUME: 16

Page Numbers: 977-82

Journal Abbreviation:

ISSN: 0961-8368

DAY: 30

MONTH: 03

YEAR: 2007

Solution structure of HI1506, a novel two-domain protein from Haemophilus influenzae. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9211750

Solution structure of HI1506, a novel two-domain protein from Haemophilus influenzae. Keywords Mesh Terms:

KEYWORDS: Solutions

MESH TERMS: metabolism

Chemical & Substance for Abstract: Solution structure of HI1506, a novel two-domain protein from Haemophilus influenzae. Information

Substance Name: Solutions

Registry Number: 0

Grant and Affiliation Information for Solution structure of HI1506, a novel two-domain protein from Haemophilus influenzae.

AFFILIATION: Center for Advanced Research in Biotechnology, University of Maryland Biotechnology Institute, Rockville, Maryland 20850, USA.

Country: United States

AGENCY: United States NIGMS

GRANT: GM57890

ACRONYM: GM

MEDLINETA: Protein Sci

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