Solution structure of an rRNA substrate bound to the pseudouridylation pocket of a box H/ACA snoRNA.

Solution structure of an rRNA substrate bound to the pseudouridylation pocket of a box H/ACA snoRNA. Research Abstract Details 

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Solution structure of an rRNA substrate bound to the pseudouridylation pocket of a box H/ACA snoRNA. Abstract Text:

Hong Jin,J Patrick Loria,Peter B Moore,

Base pairing between the RNA components of box H/ACA small nucleolar ribonucleoproteins (snoRNPs) and sequences in other eukaryotic RNAs target specific uridines for pseudouridylation. An RNA called HJ1 has been developed that interacts with the rRNA sequence targeted by the 5' pseudouridylation pocket of human U65 snoRNA the same way as intact U65 snoRNA. Sequences on both strands of the analog of the U65 snoRNP pseudouridylation pocket in HJ1 pair with its substrate sequence, and the resulting complex, called HJ3, is strongly stabilized by Mg(2+). The solution structure of HJ3 reveals an Omega-shaped RNA interaction motif that has not previously been described, which is likely to be common to all box H/ACA snoRNP-substrate complexes. The topology of the complex explains why the access of substrate sequences to snoRNPs is facile and how uridine selection may occur when these complexes form.

Solution structure of an rRNA substrate bound to the pseudouridylation pocket of a box H/ACA snoRNA. Publishing Authors By Initials

H Jin,JP Loria,PB Moore,

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MEDLINE DATE:

Solution structure of an rRNA substrate bound to the pseudouridylation pocket of a box H/ACA snoRNA. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Molecular cell

VOLUME: 26

Page Numbers: 205-15

Journal Abbreviation:

ISSN: 1097-2765

DAY: 27

MONTH: Apr

YEAR: 2007

Solution structure of an rRNA substrate bound to the pseudouridylation pocket of a box H/ACA snoRNA. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9802571

Solution structure of an rRNA substrate bound to the pseudouridylation pocket of a box H/ACA snoRNA. Keywords Mesh Terms:

KEYWORDS: Solutions

MESH TERMS: metabolism

Chemical & Substance for Abstract: Solution structure of an rRNA substrate bound to the pseudouridylation pocket of a box H/ACA snoRNA. Information

Substance Name: Magnesium

Registry Number: 7439-95-4

Grant and Affiliation Information for Solution structure of an rRNA substrate bound to the pseudouridylation pocket of a box H/ACA snoRNA.

AFFILIATION: Department of Chemistry, Yale University, New Haven, CT 06520, USA.

Country: United States

AGENCY: United States NIGMS

GRANT: GM061258

ACRONYM: GM

MEDLINETA: Mol Cell

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