Soluble TWEAK is markedly elevated in hemophagocytic lymphohistiocytosis.

Soluble TWEAK is markedly elevated in hemophagocytic lymphohistiocytosis. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Soluble TWEAK is markedly elevated in hemophagocytic lymphohistiocytosis. Abstract Text:

Masayuki Nagasawa,Zhu Yi,Shinsaku Imashuku,Shigeaki Nonoyama,Kazuyuki Ogawa,Ko Okumura,Shuki Mizutani,

Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) is a newly identified monocyte derived cytokine, which has weak apoptosis inducing function against sensitive tumor cell lines in vitro. Also, TWEAK has been reported to have proangiogenic and proinflammatory activities in vivo. However, its functions in pathological situation remain to be elucidated. Here, we analyzed soluble TWEAK in serum of 24 patients with hemophagocytic lymphohistiocytosis (HLH) in combination with interferon-gamma (IFN-gamma) and killer-specific secretory protein of 37 kDa (Ksp37). Soluble TWEAK was not detected in serum of healthy individuals. Soluble TWEAK was markedly elevated in all six primary HLH patients and 12 of 18 secondary HLH patients. Serum IFN-gamma, which is an only known mediator to stimulate TWEAK production in monocyte in vitro, was not elevated despite elevated serum TWEAK in three of six primary HLH patients, although IFN-gamma was markedly elevated in other cases. Ksp37 was only slightly increased in HLH patients. These results indicate that TWEAK may be involved in pathogenesis of HLH and is useful as a clinical marker. Am. J. Hematol., 2008. (c) 2007 Wiley-Liss, Inc.

Soluble TWEAK is markedly elevated in hemophagocytic lymphohistiocytosis. Publishing Authors By Initials

M Nagasawa,Z Yi,S Imashuku,S Nonoyama,K Ogawa,K Okumura,S Mizutani,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Soluble TWEAK is markedly elevated in hemophagocytic lymphohistiocytosis. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: American journal of hematology

VOLUME: 83

Page Numbers: 222-5

Journal Abbreviation: Am. J. Hematol.

ISSN: 0361-8609

DAY: 4

MONTH: Mar

YEAR: 2008

Soluble TWEAK is markedly elevated in hemophagocytic lymphohistiocytosis. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7610369

Soluble TWEAK is markedly elevated in hemophagocytic lymphohistiocytosis. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Soluble TWEAK is markedly elevated in hemophagocytic lymphohistiocytosis. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Soluble TWEAK is markedly elevated in hemophagocytic lymphohistiocytosis.

AFFILIATION: Department of Pediatrics and Developmental Biology, Postgraduate School of Medicine, Tokyo Medical and Dental University, Tokyo, Japan.

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Am J Hematol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Soluble TWEAK is markedly elevated in hemophagocytic lymphohistiocytosis Related Publications

• A case of Adamantiades-Behçet disease with ischemic optic neuritis (posterior optic neuropathy).
• Adsorption chromatography of nucleic acids on silicone-coated porous glass.
• Chemical modification of pseudouridylic acid in isoeleucine transfer ribonucleic acid from Torulopsis utilis with a radioactive carbodiimide.
• Chemical modification of pseudouridylic acid in valine transfer ribonucleic acid I from Torulopsis utilis with a radioactive carbodiimide.
• Effect of low-intensity back exercise on quality of life and back extensor strength in patients with osteoporosis: a randomized controlled trial.
• Isolation of Novel Adenovirus from Fruit Bat (Pteropus dasymallus yayeyamae).
• Lymphocyte-increasing action and hypocalcemic action of parotid gland extract.
• Magnetic resonance (MR) imaging-induced deep second-degree burns of lower extremities by conducting loop.
• Necrobiotic xanthogranuloma with paraproteinemia; an atypical case.
• Neuroendocrine carcinoma of the stomach with peripancreatic lymph node metastases successfully treated with pancreaticoduodenectomy.
• Oxidative stress in neurodegeneration in dentatorubral-pallidoluysian atrophy.
• Primary protein response after ligand photodissociation in carbonmonoxy myoglobin.
• Rapid determination of viral RNA sequences in mosquitoes collected in the field.
• Serum granulysin is elevated in patients with hemophagocytic lymphohistiocytosis.
• Silver stainings distinguish Lewy bodies and glial cytoplasmic inclusions: comparison between Gallyas-Braak and Campbell-Switzer methods.
• Soluble TWEAK is markedly elevated in hemophagocytic lymphohistiocytosis.
• Structure determination of structurally complex Ag36Li64 gamma-brass.
• Target scattering waves emitted from a time reversal array in shallow water.
• The reversible chemical modification of valine transfer ribonucleic acid I from Torulopsis with a radioactive carbodiimide.
• [Contact lens wearing and corneal changes]
• [Correlation between molecular evolution of P450s and evolution of plant secondary metabolism]
• [Etiology on the formation of the dimples of the central epithelium of the cornea associated with the wearing of corneal contact lens]
• [Leukoencephalopathy]
• [Man and language]
• [Mechanism of DNA damage and apoptosis induced by anticancer drugs through generation of reactive oxygen species]
• [OPTICAL ZONE OF CONTACT LENSES.]
• [Remarks on the examination of nursing needs; with special reference to the instruction of pre- and postoperative nursing]
• [The clinical effect of antibiotics in the macrolide family on bronchial asthma. Non-antimicrobial actions of oleandomycin [author's transl)]
• [The clinical importance of contact lens hydration]
• [The effects of contact lenses on the human cornea. I. Clinical experiment and corneal changes]