Soluble transferrin receptor-1 levels in mice do not affect iron absorption.

Soluble transferrin receptor-1 levels in mice do not affect iron absorption. Research Abstract Details 

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Soluble transferrin receptor-1 levels in mice do not affect iron absorption. Abstract Text:

Jonathan M Flanagan,Hongfan Peng,Lei Wang,Terri Gelbart,Pauline Lee,Barbra Johnson Sasu,Ernest Beutler,

Soluble transferrin receptor-1 (sTfR1) concentrations are increased in the plasma under two conditions that are associated with increased iron absorption, i.e. iron deficiency and increased erythropoiesis. To determine the possible role of sTfR1 as a signaling mechanism for iron absorption, a hydrodynamic gene transfer technique was established to express transfected plasmid constructs of human sTfR1 (hsTfR1) and murine sTfR1 (msTfR1) from the livers of C57BL/6 mice. Iron absorption, serum iron levels and hepcidin expression were then measured. The hydrodynamic gene transfer technique proved to be an effective approach to achieving sustained expression of sTfR1 in mice. Although expression of high levels of sTfR1 significantly increased serum iron levels, repeated experiments showed that neither hsTfR1 nor msTfR1 had any effect on iron absorption or hepcidin mRNA expression levels. Thus, despite its attractiveness as a potential modifier of iron absorption, sTfR1 levels do not exert a regulatory effect on iron absorption.

Soluble transferrin receptor-1 levels in mice do not affect iron absorption. Publishing Authors By Initials

JM Flanagan,H Peng,L Wang,T Gelbart,P Lee,B Johnson Sasu,E Beutler,

For similar natural sciences: chemistry: chemistry, physical: solubility research abstracts see: natural sciences: chemistry: chemistry, physical: solubility research

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Soluble transferrin receptor-1 levels in mice do not affect iron absorption. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Acta haematologica

VOLUME: 116

Page Numbers: 249-54

Journal Abbreviation: Acta Haematol.

ISSN: 0001-5792

DAY: 3

MONTH: 12

YEAR: 2006

Soluble transferrin receptor-1 levels in mice do not affect iron absorption. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 141053

Soluble transferrin receptor-1 levels in mice do not affect iron absorption. Keywords Mesh Terms:

KEYWORDS: Solubility

MESH TERMS: physiology

Chemical & Substance for Abstract: Soluble transferrin receptor-1 levels in mice do not affect iron absorption. Information

Substance Name: Iron

Registry Number: 7439-89-6

Grant and Affiliation Information for Soluble transferrin receptor-1 levels in mice do not affect iron absorption.

AFFILIATION: Department of Molecular and Experimental Medicine, Scripps Research Institute, MEM-215, La Jolla, CA 92037, USA.

Country: Switzerland

AGENCY: United States NIDDK

GRANT: DK53505-08

ACRONYM: DK

MEDLINETA: Acta Haematol

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