Soluble epoxide hydrolase: regulation by estrogen and role in the inflammatory response to cerebral ischemia.

Soluble epoxide hydrolase: regulation by estrogen and role in the inflammatory response to cerebral ischemia. Research Abstract Details 

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Soluble epoxide hydrolase: regulation by estrogen and role in the inflammatory response to cerebral ischemia. Abstract Text:

Ines P Koerner,Wenri Zhang,Jian Cheng,Susan Parker,Patricia D Hurn,Nabil J Alkayed,Ines P Koerner,Wenri Zhang,Jian Cheng,Susan Parker,Patricia D Hurn,Nabil J Alkayed,

The protection from ischemic brain injury enjoyed by females is linked to the female sex hormone 17beta-estradiol. We tested the hypothesis that neuroprotection by estradiol entails the prevention of ischemia-induced inflammatory response, through suppression of the P450 eicosanoids-metabolizing enzyme soluble epoxide hydrolase (sEH). Ovariectomized female rats with and without estradiol replacement underwent 2-hour middle cerebral artery occlusion (MCAO). SEH expression was determined using Western blot, and inflammatory cytokine mRNA levels were measured at 6, 24 and 48 hours after MCAO. Cytokine mRNA was also measured in sEH-knockout mice, and in rats treated with sEH inhibitors. Estradiol reduced basal and post-ischemic sEH expression. MCAO strongly induced mRNA levels of tumor necrosis factor-alpha, interleukin 6, and interleukin 1beta, which was attenuated in sEH-knockouts, but not by sEH inhibitors. Estradiol replacement exhibited a bimodal effect on cytokine mRNA, with increased early and reduced delayed expression. While estradiol suppresses cerebral sEH expression, and sEH suppression diminishes inflammation after MCAO, our findings suggest that the effect of estrogen on inflammation is complex, and only partially explained by sEH suppression.

Soluble epoxide hydrolase: regulation by estrogen and role in the inflammatory response to cerebral ischemia. Publishing Authors By Initials

IP Koerner,W Zhang,J Cheng,S Parker,PD Hurn,NJ Alkayed,IP Koerner,W Zhang,J Cheng,S Parker,PD Hurn,NJ Alkayed,

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Soluble epoxide hydrolase: regulation by estrogen and role in the inflammatory response to cerebral ischemia. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Frontiers in bioscience : a journal and virtual li

VOLUME: 13

Page Numbers: 2833-41

Journal Abbreviation: Front. Biosci.

ISSN: 1093-4715

DAY: 1

MONTH: 01

YEAR: 2008

Soluble epoxide hydrolase: regulation by estrogen and role in the inflammatory response to cerebral ischemia. Information

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LANGUAGE: eng

NlmUniqueID: 9709506

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Grant and Affiliation Information for Soluble epoxide hydrolase: regulation by estrogen and role in the inflammatory response to cerebral ischemia.

AFFILIATION: Department of Anesthesiology and Peri-Operative Medicine, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA.

Country: United States

AGENCY: United States NINDS

GRANT: NS44313

ACRONYM: NS

MEDLINETA: Front Biosci

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