[Soluble CD4 antigens in the cerebrospinal fluid as a marker of lymphocytic infiltration of the central nervous system]

[Soluble CD4 antigens in the cerebrospinal fluid as a marker of lymphocytic infiltration of the central nervous system] Research Abstract Details 

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[Soluble CD4 antigens in the cerebrospinal fluid as a marker of lymphocytic infiltration of the central nervous system] Abstract Text:

Miodrag Vrbi?,Svetislav Vrbi?,Snezana Skori?,Vesna Mihailovi?,Zarko Rankovi?,Ljiljana Konstantinovi?,Velimir Kosti?,Milijanka Krsti?,Maja Jovanovi?,

Early diagnosis of the central nervous system (CNS) infections is a precondition of their successful treatment. However, the essential standard examination of the cerebrospinal fluid (CSF) is sometimes neither specific enough to define their basic nature, nor sufficient to differentiate them from processes of non-infectious origin. Supposing that the released surface molecules of activated immunocompetent cells could better define the character of inflammatory reaction, the levels of soluble CD4 antigens (sCD4) were determined with enzyme-immunosorbent test in the CSF of the patients with various CNS diseases. In contrast to cerebrovascular insults, toxic-metabolic, and other conditions in control group, detectable sCD4 concentrations in acute encephalitis (24 +/- 11 U/ml) were verified at the beginning of the disease, being also present in cytologically diagnosed normal CSF findings. They were significantly higher (p<0.05) compared to acute serous meningitis (13.5 +/- 8 U/ml), while in purulent meningitis they were measurable only after the disease progression--in correlation with the disturbed brain system function. The obtained results suggested the significance of CD4 antigen levels in CSF as a sensitive and specific marker of lymphocytic infiltration of the brain parenchyma, the measurement of which could contribute to early identification of the CNS infections, better understanding of their pathogenesis, and the assessment of the actual level of the destruction of neurons.

[Soluble CD4 antigens in the cerebrospinal fluid as a marker of lymphocytic infiltration of the central nervous system] Publishing Authors By Initials

M Vrbi?,S Vrbi?,S Skori?,V Mihailovi?,Z Rankovi?,L Konstantinovi?,V Kosti?,M Krsti?,M Jovanovi?,

For similar investigative techniques: epidemiologic methods: statistics as topic: sensitivity and specificity research abstracts see: investigative techniques: epidemiologic methods: statistics as topic: sensitivity and specificity research

PUBMED ID PMID:

MEDLINE DATE: 2004 May-Jun

[Soluble CD4 antigens in the cerebrospinal fluid as a marker of lymphocytic infiltration of the central nervous system] Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Vojnosanitetski pregled. Military-medical and phar

VOLUME: 61

Page Numbers: 247-53

Journal Abbreviation:

ISSN: 0042-8450

DAY: 9

MONTH: 01

YEAR: 2008

[Soluble CD4 antigens in the cerebrospinal fluid as a marker of lymphocytic infiltration of the central nervous system] Information

Number of References:

LANGUAGE: scc

NlmUniqueID: 21530700

[Soluble CD4 antigens in the cerebrospinal fluid as a marker of lymphocytic infiltration of the central nervous system] Keywords Mesh Terms:

KEYWORDS: Sensitivity and Specificity

MESH TERMS: pathology

Chemical & Substance for Abstract: [Soluble CD4 antigens in the cerebrospinal fluid as a marker of lymphocytic infiltration of the central nervous system] Information

Substance Name: Biological Markers

Registry Number: 0

Grant and Affiliation Information for [Soluble CD4 antigens in the cerebrospinal fluid as a marker of lymphocytic infiltration of the central nervous system]

AFFILIATION: Klinicki centar, Klinika za infektivne bolesti, Nis. mvrbic@eunet.yu

Country: Yugoslavia

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MEDLINETA: Vojnosanit Pregl

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