Solubilisation of drugs in worm-like micelles of block copolymers of ethylene oxide and 1,2-butylene oxide in aqueous solution.

Solubilisation of drugs in worm-like micelles of block copolymers of ethylene oxide and 1,2-butylene oxide in aqueous solution. Research Abstract Details 

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Solubilisation of drugs in worm-like micelles of block copolymers of ethylene oxide and 1,2-butylene oxide in aqueous solution. Abstract Text:

Zhengyuan Zhou,Chiraphon Chaibundit,Antony D'Emanuele,Kieran Lennon,David Attwood,Colin Booth,

Ethylene oxide and 1,2-butylene oxide were sequentially polymerised to form the diblock copolymer E(13)B(10) (E=oxyethylene, B=oxybutylene, subscripts denote number-average block lengths in repeat units). Dynamic and static light scattering over the temperature range 10-30 degrees C demonstrated a transition from compact (spheroidal) micelles to larger, more elongated (worm-like) micelles with temperature increase above a critical onset temperature of about 20 degrees C. Determination of the solubilisation capacity for griseofulvin, carbamazepine and spironolactone of dilute micellar solutions of this copolymer, together with those of E(11)B(8) and E(17)B(12) block copolymers (which also show the sphere-to-worm transition), allowed investigation of the influence on solubilisation characteristics of hydrophobic block length and temperature. The extent of solubilisation at 25 degrees C of the poorly water-soluble drug spironolactone increased linearly with increase of hydrophobic block length, attributable to a concomitant increase in the proportion of worm-like micelles in solution.

Solubilisation of drugs in worm-like micelles of block copolymers of ethylene oxide and 1,2-butylene oxide in aqueous solution. Publishing Authors By Initials

Z Zhou,C Chaibundit,A D'Emanuele,K Lennon,D Attwood,C Booth,

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Solubilisation of drugs in worm-like micelles of block copolymers of ethylene oxide and 1,2-butylene oxide in aqueous solution. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: International journal of pharmaceutics

VOLUME: 354

Page Numbers: 82-7

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ISSN: 0378-5173

DAY: 30

MONTH: 10

YEAR: 2007

Solubilisation of drugs in worm-like micelles of block copolymers of ethylene oxide and 1,2-butylene oxide in aqueous solution. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Solubilisation of drugs in worm-like micelles of block copolymers of ethylene oxide and 1,2-butylene oxide in aqueous solution.

AFFILIATION: School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Manchester M13 9PL, UK.

Country: Netherlands

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MEDLINETA: Int J Pharm

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