Solitary fibrous tumor of the orbit: morphological, cytogenetic and molecular features.

Solitary fibrous tumor of the orbit: morphological, cytogenetic and molecular features. Research Abstract Details 

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Solitary fibrous tumor of the orbit: morphological, cytogenetic and molecular features. Abstract Text:

Solitary fibrous tumor (SFT), a benign neoplasm arising in mesenchymal structures, was initially described in the pleura but subsequently has also been documented in other locations. It is uncommon in the orbit, where it closely resembles other benign spindle-shaped mesenchymal tumors of this area such as schwannoma, meningioma or hemangiopericytoma. We present a case of orbital SFT in a 34-year-old woman. The radiological study showed the presence of an enhanced uptake lesion measuring 2 cm in major diameter. The histopathological evaluation revealed alternating cellular and hypocellular areas with spindle-shaped cells. The cellular organization displayed a broad variety of irregular morphological patterns. The neoplastic cells were intensely positive for CD34 and vimentin, while S100, epithelial membrane antigen (EMA), Caldesmon, Calretinin and WT-1 proved negative. The pericellular matrix exhibited strong positivity for CD44 and collagen IV. Scarce mitotic figures, a Ki-67 nuclear labeling index of <5%, and focal expression of p53 were also observed. Measurement of DNA content revealed a DNA index of 1, indicating a diploid peak in 95% of the tumor cells. A normal 46,XX karyotype was present. No TP53 (exons 5-8) mutations or MDM2 and CDK4 amplifications were observed. No p14(ARF), p15(INK4B) and p16(INK4A) deletions or hypermethylation were observed in this benign tumor. Following surgical resection and radiotherapy, the patient showed no tumor relapse after one year of follow-up.

Solitary fibrous tumor of the orbit: morphological, cytogenetic and molecular features. Publishing Authors By Initials

For similar proteins: cell cycle proteins: tumor suppressor protein p14arf research abstracts see: proteins: cell cycle proteins: tumor suppressor protein p14arf research

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Solitary fibrous tumor of the orbit: morphological, cytogenetic and molecular features. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Neuropathology : official journal of the Japanese

VOLUME: 26

Page Numbers: 557-63

Journal Abbreviation: Neuropathology

ISSN: 0919-6544

DAY: 10

MONTH: Dec

YEAR: 2006

Solitary fibrous tumor of the orbit: morphological, cytogenetic and molecular features. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9606526

Solitary fibrous tumor of the orbit: morphological, cytogenetic and molecular features. Keywords Mesh Terms:

KEYWORDS: Tumor Suppressor Protein p14ARF

MESH TERMS: genetics

Chemical & Substance for Abstract: Solitary fibrous tumor of the orbit: morphological, cytogenetic and molecular features. Information

Substance Name: Proto-Oncogene Proteins c-mdm2

Registry Number: EC 6.3.2.19

Grant and Affiliation Information for Solitary fibrous tumor of the orbit: morphological, cytogenetic and molecular features.

AFFILIATION: Department of Pathology, Valencia University, Valencia University Clinic Hospital, Valencia, Spain. jose.m.cerda@uv.es

Country: Australia

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MEDLINETA: Neuropathology

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