The synthesis of a focused library of jasplakinolide analogs with a 1,2,3-triazole in place of an E-configured double bond is described, featuring the Cu(I) catalyzed azide-alkyne cycloaddition reaction as an efficient macrocyclization tool.
Solid-phase based synthesis of jasplakinolide analogs by intramolecular azide-alkyne cycloadditions. Publishing Authors By Initials