Solenopsin, the alkaloidal component of the fire ant (Solenopsis invicta), is a naturally occurring inhibitor of phosphatidylinositol-3-kinase signaling and angiogenesis.

Solenopsin, the alkaloidal component of the fire ant (Solenopsis invicta), is a naturally occurring inhibitor of phosphatidylinositol-3-kinase signaling and angiogenesis. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Solenopsin, the alkaloidal component of the fire ant (Solenopsis invicta), is a naturally occurring inhibitor of phosphatidylinositol-3-kinase signaling and angiogenesis. Abstract Text:

Jack L Arbiser,Tweeny Kau,Martha Konar,Krishna Narra,Ramani Ramchandran,Scott A Summers,Chris J Vlahos,Keqiang Ye,Betsy N Perry,William Matter,Anthony Fischl,James Cook,Pamela A Silver,Jenny Bain,Philip Cohen,David Whitmire,Scott Furness,Baskaran Govindarajan,J Phillip Bowen,

Phosphatidylinositol-3-kinase (PI3K), and its downstream effector Akt, or protein kinase Balpha (PKBalpha), play a major regulatory role in control of apoptosis, proliferation, and angiogenesis. PI3K and Akt are amplified or overexpressed in a number of malignancies, including sarcomas, ovarian cancer, multiple myeloma, and melanoma. This pathway regulates production of the potent angiogenic factor vascular endothelial growth factor (VEGF), and protects tumor cells against both chemotherapy and reactive oxygen-induced apoptosis through phosphorylation of substrates such as apoptotic peptidase-activating factor-1 (APAF-1), forkhead proteins, and caspase 9. Given its diverse actions, compounds that suppress the PI3K/Akt pathway have potential pharmacologic utility as angiogenesis inhibitors and antineoplastic agents. Using the SVR angiogenesis assay, a screen of natural products, we isolated the alkaloid solenopsin, and found that it is a potent angiogenesis inhibitor. We also found that solenopsin inhibits the PI3K signaling pathway in cells upstream of PI3K, which may underlie its affects on angiogenesis. Consistent with inhibition of the activation of PI3K, solenopsin prevented the phosphorylation of Akt and the phosphorylation of its substrate forkhead box 01a (FOXO1a), a member of the forkhead family of transcription factors. Interestingly, solenopsin also inhibited Akt-1 activity in an ATP-competitive manner in vitro without affecting 27 of 28 other protein kinases tested.

Solenopsin, the alkaloidal component of the fire ant (Solenopsis invicta), is a naturally occurring inhibitor of phosphatidylinositol-3-kinase signaling and angiogenesis. Publishing Authors By Initials

JL Arbiser,T Kau,M Konar,K Narra,R Ramchandran,SA Summers,CJ Vlahos,K Ye,BN Perry,W Matter,A Fischl,J Cook,PA Silver,J Bain,P Cohen,D Whitmire,S Furness,B Govindarajan,JP Bowen,

For similar animals: chordata: vertebrates: fishes: cypriniformes: cyprinidae: zebrafish research abstracts see: animals: chordata: vertebrates: fishes: cypriniformes: cyprinidae: zebrafish research

PUBMED ID PMID:

MEDLINE DATE:

Solenopsin, the alkaloidal component of the fire ant (Solenopsis invicta), is a naturally occurring inhibitor of phosphatidylinositol-3-kinase signaling and angiogenesis. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Blood

VOLUME: 109

Page Numbers: 560-5

Journal Abbreviation: Blood

ISSN: 0006-4971

DAY: 21

MONTH: 09

YEAR: 2006

Solenopsin, the alkaloidal component of the fire ant (Solenopsis invicta), is a naturally occurring inhibitor of phosphatidylinositol-3-kinase signaling and angiogenesis. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7603509

Solenopsin, the alkaloidal component of the fire ant (Solenopsis invicta), is a naturally occurring inhibitor of phosphatidylinositol-3-kinase signaling and angiogenesis. Keywords Mesh Terms:

KEYWORDS: Zebrafish

MESH TERMS: embryology

Chemical & Substance for Abstract: Solenopsin, the alkaloidal component of the fire ant (Solenopsis invicta), is a naturally occurring inhibitor of phosphatidylinositol-3-kinase signaling and angiogenesis. Information

Substance Name: Protein Kinases

Registry Number: EC 2.7.1.37

Grant and Affiliation Information for Solenopsin, the alkaloidal component of the fire ant (Solenopsis invicta), is a naturally occurring inhibitor of phosphatidylinositol-3-kinase signaling and angiogenesis.

AFFILIATION: Department of Dermatology, Emory University School of Medicine, WMB 5309, 101 Woodruff Circle, Atlanta, GA 30322, USA. jarbise@emory.edu

Country: United States

AGENCY: United States NIAMS

GRANT: R01 AR47901

ACRONYM: AR

MEDLINETA: Blood

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Solenopsin, the alkaloidal component of the fire ant Solenopsis invicta, is a naturally occurring inhibitor of phosphatidylinositol-3-kinase signaling and angiogenesis Related Publications

• Acute onset left hemiparesis and facial droop in a 37 year old soccer player: 1123: june 1 3:15 PM - 3:35 PM.
• C1584 in von Willebrand factor is necessary for enhanced proteolysis by ADAMTS13 in vitro.
• Chain of custody as an organizing framework in seafood risk reduction.
• Complex palliative care and transition: a case review.
• Decontaminable surfaces for millicurie-level laboratories.
• Determination of cell colony formation in a high-content screening assay.
• Duplications involving int22h-1 of the factor VIII gene: a cause for concern in genetic testing for hemophilia A?
• Dynamics of passive immunity to West Nile virus in domestic chickens (Gallus gallus domesticus).
• Electron-cytochemical localization of acid phosphatase activity in the digestive caeca of the desert locust.
• Failure to induce an antiviral state in preimplantation bovine embryos treated with interferon.
• Health impact assessments in London: assessing the London Mayoral strategies.
• Increases in amphetamine-like discriminative stimulus effects of the abused inhalant toluene in mice.
• MR angiography versus CT angiography in the evaluation of neurovascular disease.
• Methods and normal values for echocardiography in adult dairy cattle.
• Photoelectron spectroscopy of hydrated adenine anions.
• Predictors of self-referral into a cancer genetics registry.
• Raloxifene and selective cell cycle specific agents: a case for the inclusion of raloxifene in current breast cancer treatment therapies.
• Results of a randomized study of telephone versus in-person breast cancer risk counseling.
• Salivary glucosyltransferase B as a possible marker for caries activity.
• Self-rated breast cancer risk among women reporting a first-degree family history of breast cancer on office screening questionnaires in routine medical care: the role of physician-delivered risk feedback.
• Sequence-dependent administration of raloxifene and 5-fluorouracil/pemetrexed protects against pemetrexed cytotoxicity in human bone marrow.
• Sequential combination chemotherapy in human breast cancer: a basis for increased antineoplastic activity and bone marrow protection.
• Solenopsin, the alkaloidal component of the fire ant (Solenopsis invicta), is a naturally occurring inhibitor of phosphatidylinositol-3-kinase signaling and angiogenesis.
• The cancer worry chart: a single-item screening measure of worry about developing breast cancer.
• The correction of leg-length discrepancy after treatment in developmental dysplasia of the hip by using a percutaneous epiphysiodesis.
• The effects of methyltestosteone on reproductive function in male greyhounds.
• The effects of prostalene and alfaprostol as uterine myotonics, and the effect on postpartum pregnancy rate in the mare following daily treatment with prostalene.
• The impact of HIV-related interventions on HIV risk behavior in a community sample of African American crack cocaine users.
• The protection against trimetrexate cytotoxicity in human bone marrow by sequence-dependent administration of raloxifene, 5-fluorouracil/trimetrexate.
• Use of the statistical properties of the wavelet-transform coefficients for optimization of integration time in Fourier transform spectrometry.