Soft tissue adhesive composed of modified gelatin and polysaccharides.

Soft tissue adhesive composed of modified gelatin and polysaccharides. Research Abstract Details 

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Soft tissue adhesive composed of modified gelatin and polysaccharides. Abstract Text:

X Mo,H Iwata,S Matsuda,Y Ikada,

Although fibrin glue has been clinically used as a surgical adhesive, hemostatic agent, and sealant, it has the risk of virus infection because its components, fibrinogen and thrombin, are obtained from human blood. To circumvent this problem, we employed bioabsorbable gelatin and polysaccharides to prepare a safer hemostatic glue. Gelatin was modified with ethylenediamine using water-soluble carbodiimide to introduce additional amino groups into the original gelatin, while dextran and hydroxyethyl-starch were oxidized by sodium periodate to convert 1,2-hydroxyl groups into dialdehyde groups. Upon mixing of the two polymer components in aqueous solution, Schiff base was formed between the amino groups in the modified gelatin and the aldehyde groups in the modified polysaccharides, which thus resulted in intermolecular cross-linking and gel formation. The fastest gel formation took place within 2 s, and its bonding strength to porcine skin was about 225 gf cm(-2) when 20 wt% of an amino-gelatin (55% amino) and 10 wt% of aldehyde-HES (>84% dialdehyde) aqueous solutions were mixed. In contrast, the gelation time and bonding strength of fibrin glue was 5 s and 120 gf cm(-2), respectively.

Soft tissue adhesive composed of modified gelatin and polysaccharides. Publishing Authors By Initials

X Mo,H Iwata,S Matsuda,Y Ikada,

For similar natural sciences: time: time factors research abstracts see: natural sciences: time: time factors research

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Soft tissue adhesive composed of modified gelatin and polysaccharides. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of biomaterials science. Polymer edition

VOLUME: 11

Page Numbers: 341-51

Journal Abbreviation:

ISSN: 0920-5063

DAY: 20

MONTH: 02

YEAR: 2000

Soft tissue adhesive composed of modified gelatin and polysaccharides. Information

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LANGUAGE: eng

NlmUniqueID: 9007393

Soft tissue adhesive composed of modified gelatin and polysaccharides. Keywords Mesh Terms:

KEYWORDS: Time Factors

MESH TERMS: metabolism

Chemical & Substance for Abstract: Soft tissue adhesive composed of modified gelatin and polysaccharides. Information

Substance Name: Dextrans

Registry Number: 9004-54-0

Grant and Affiliation Information for Soft tissue adhesive composed of modified gelatin and polysaccharides.

AFFILIATION: Institute for Frontier Medical Science, Kyoto University, Shogoin, Japan.

Country: NETHERLANDS

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MEDLINETA: J Biomater Sci Polym Ed

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