Sodium currents in mesencephalic trigeminal neurons from Nav1.6 null mice.

Sodium currents in mesencephalic trigeminal neurons from Nav1.6 null mice. Research Abstract Details 

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Sodium currents in mesencephalic trigeminal neurons from Nav1.6 null mice. Abstract Text:

Akifumi Enomoto,Juliette M Han,Chie-Fang Hsiao,Scott H Chandler,Akifumi Enomoto,Juliette M Han,Chie-Fang Hsiao,Scott H Chandler,

Previous studies using pharmacological methods suggest that subthreshold sodium currents are critical for rhythmical burst generation in mesencephalic trigeminal neurons (Mes V). In this study, we characterized transient (I(NaT)), persistent (I(N)(aP)), and resurgent (I(res)) sodium currents in Na(v)1.6-null mice (med mouse, Na(v)1.6(-/-)) lacking expression of the sodium channel gene Scn8a. We found that peak transient, persistent, and resurgent sodium currents from med (Na(v)1.6(-/-)) mice were reduced by 18, 39, and 76% relative to their wild-type (Na(v)1.6(+/+)) littermates, respectively. Current clamp recordings indicated that, in response to sinusoidal constant amplitude current (ZAP function), all neurons exhibited membrane resonance. However, Mes V neurons from med mice had reduced peak amplitudes in the impedance-frequency relationship (resonant Q-value) and attenuated subthreshold oscillations despite the similar passive membrane properties compared with wild-type littermates. The spike frequency-current relationship exhibited reduced instantaneous discharge frequencies and spike block at low stimulus currents and seldom showed maintained spike discharge throughout the stimulus in the majority of med neurons compared with wild-type neurons. Importantly, med neurons never exhibited maintained stimulus-induced rhythmical burst discharge unlike those of wild-type littermates. The data showed that subthreshold sodium currents are critical determinants of Mes V electrogenesis and burst generation and suggest a role for resurgent sodium currents in control of spike discharge.

Sodium currents in mesencephalic trigeminal neurons from Nav1.6 null mice. Publishing Authors By Initials

A Enomoto,JM Han,CF Hsiao,SH Chandler,A Enomoto,JM Han,CF Hsiao,SH Chandler,

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Sodium currents in mesencephalic trigeminal neurons from Nav1.6 null mice. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Journal of neurophysiology

VOLUME: 98

Page Numbers: 710-9

Journal Abbreviation: J. Neurophysiol.

ISSN: 0022-3077

DAY: 23

MONTH: 05

YEAR: 2007

Sodium currents in mesencephalic trigeminal neurons from Nav1.6 null mice. Information

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LANGUAGE: eng

NlmUniqueID: 375404

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Grant and Affiliation Information for Sodium currents in mesencephalic trigeminal neurons from Nav1.6 null mice.

AFFILIATION: Department of Physiological Science, University of California, Los Angeles, California 90095, USA.

Country: United States

AGENCY: United States NIDCR

GRANT: DE-06193

ACRONYM: DE

MEDLINETA: J Neurophysiol

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