Social stimuli enhance phencyclidine (PCP) self-administration in rhesus monkeys.

Social stimuli enhance phencyclidine (PCP) self-administration in rhesus monkeys. Research Abstract Details 

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Social stimuli enhance phencyclidine (PCP) self-administration in rhesus monkeys. Abstract Text:

Jennifer L Newman,Jennifer L Perry,Marilyn E Carroll,

Environmental factors, including social interaction, can alter the effects of drugs of abuse on behavior. The present study was conducted to examine the effects of social stimuli on oral phencyclidine (PCP) self-administration by rhesus monkeys. Ten adult rhesus monkeys (M. mulatta) were housed side by side in modular cages that could be configured to provide visual, auditory, and olfactory stimuli provided by another monkey located in the other side of a paired unit. During the first experiment, monkeys self-administered PCP (0.25 mg/ml) and water under concurrent fixed ratio (FR) 16 schedules of reinforcement with either a solid or a grid (social) partition separating each pair of monkeys. In the second experiment, a PCP concentration-response relationship was determined under concurrent progressive ratio (PR) schedules of reinforcement during both the solid and grid partition conditions. Under the concurrent FR 16 schedules, PCP and water self-administration were significantly higher during exposure to a cage mate through a grid partition than when a solid partition separated the monkeys. The relative reinforcing strength of PCP, as measured by PR break points, was greater during the grid partition condition compared to the solid partition condition indicated by an upward shift in the concentration-response curve. To determine whether the social stimuli provided by another monkey led to activation of the hypothalamic-pituitary-adrenal (HPA) axis, which may have evoked the increase of PCP self-administration during the grid partition condition, a third experiment was conducted to examine cortisol levels under the two housing conditions. A modest, but nonsignificant increase in cortisol levels was found upon switching from the solid to the grid partition condition. The results suggest that social stimulation among monkeys in adjoining cages leads to enhanced reinforcing strength of PCP.

Social stimuli enhance phencyclidine (PCP) self-administration in rhesus monkeys. Publishing Authors By Initials

JL Newman,JL Perry,ME Carroll,

For similar behavior and behavior mechanisms: behavior: behavioral symptoms: stress, psychological research abstracts see: behavior and behavior mechanisms: behavior: behavioral symptoms: stress, psychological research

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Social stimuli enhance phencyclidine (PCP) self-administration in rhesus monkeys. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Pharmacology, biochemistry, and behavior

VOLUME: 87

Page Numbers: 280-8

Journal Abbreviation: Pharmacol. Biochem. Behav.

ISSN: 0091-3057

DAY: 13

MONTH: 05

YEAR: 2007

Social stimuli enhance phencyclidine (PCP) self-administration in rhesus monkeys. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 367050

Social stimuli enhance phencyclidine (PCP) self-administration in rhesus monkeys. Keywords Mesh Terms:

KEYWORDS: Stress, Psychological

MESH TERMS: psychology

Chemical & Substance for Abstract: Social stimuli enhance phencyclidine (PCP) self-administration in rhesus monkeys. Information

Substance Name: Phencyclidine

Registry Number: 77-10-1

Grant and Affiliation Information for Social stimuli enhance phencyclidine (PCP) self-administration in rhesus monkeys.

AFFILIATION: Department of Psychiatry, University of Minnesota Medical School, MMC 392, Minneapolis, MN 55455, United States. newma210@umn.edu

Country: United States

AGENCY: United States NIDA

GRANT: T32 DA07097-24

ACRONYM: DA

MEDLINETA: Pharmacol Biochem Behav

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