Social networks and inflammatory markers in the Framingham Heart Study.

Social networks and inflammatory markers in the Framingham Heart Study. Research Abstract Details 

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Social networks and inflammatory markers in the Framingham Heart Study. Abstract Text:

Eric B Loucks,Lisa M Sullivan,Ralph B D'Agostino,Martin G Larson,Lisa F Berkman,Emelia J Benjamin,

Lack of social integration predicts coronary heart disease mortality in prospective studies; however, the biological pathways that may be responsible are poorly understood. The specific aims of this study were to examine whether social networks are associated with serum concentrations of the inflammatory markers interleukin-6 (IL-6), C-reactive protein (CRP), soluble intercellular adhesion molecule-1 (sICAM-1) and monocyte chemoattractant protein-1 (MCP-1). Participants in the Framingham Study attending examinations from 1998 to 2001 (n=3267) were eligible for inclusion in the study. Social networks were assessed using the Berkman-Syme Social Network Index (SNI). Concentrations of IL-6, CRP, sICAM-1 and MCP-1 were measured in fasting serum samples. Multivariable linear regression analyses were used to assess the association of social networks with inflammatory markers adjusting for potential confounders including age, smoking, blood pressure, total:HDL cholesterol ratio, body mass index, lipid-lowering and antihypertensive medication, diabetes, cardiovascular disease, depression and socioeconomic status. Results found that the SNI was significantly inversely associated with IL-6 in men (p=0.03) after adjusting for potential confounders. In age-adjusted analyses, social networks also were significantly inversely associated with IL-6 for women (p=0.03) and were marginally to modestly associated with CRP and sICAM-1 for men (p=0.08 and 0.02, respectively), but these associations were not significant in the multivariate analyses. In conclusion, social networks were found to be inversely associated with interleukin-6 levels in men. The possibility that inflammatory markers may be potential mediators between social integration and coronary heart disease merits further investigation.

Social networks and inflammatory markers in the Framingham Heart Study. Publishing Authors By Initials

EB Loucks,LM Sullivan,RB D'Agostino,MG Larson,LF Berkman,EJ Benjamin,

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MEDLINE DATE:

Social networks and inflammatory markers in the Framingham Heart Study. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of biosocial science

VOLUME: 38

Page Numbers: 835-42

Journal Abbreviation:

ISSN: 0021-9320

DAY: 27

MONTH: 01

YEAR: 2006

Social networks and inflammatory markers in the Framingham Heart Study. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 177346

Social networks and inflammatory markers in the Framingham Heart Study. Keywords Mesh Terms:

KEYWORDS: United States

MESH TERMS: epidemiology

Chemical & Substance for Abstract: Social networks and inflammatory markers in the Framingham Heart Study. Information

Substance Name: C-Reactive Protein

Registry Number: 9007-41-4

Grant and Affiliation Information for Social networks and inflammatory markers in the Framingham Heart Study.

AFFILIATION: Department of Society, Human Development & Health, Harvard School of Public Health, Boston, MA, USA.

Country: England

AGENCY: United States NHLBI

GRANT: N01-HC-25195

ACRONYM: HC

MEDLINETA: J Biosoc Sci

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