Small-world anatomical networks in the human brain revealed by cortical thickness from MRI.

Small-world anatomical networks in the human brain revealed by cortical thickness from MRI. Research Abstract Details 

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Small-world anatomical networks in the human brain revealed by cortical thickness from MRI. Abstract Text:

Yong He,Zhang J Chen,Alan C Evans,

An important issue in neuroscience is the characterization for the underlying architectures of complex brain networks. However, little is known about the network of anatomical connections in the human brain. Here, we investigated large-scale anatomical connection patterns of the human cerebral cortex using cortical thickness measurements from magnetic resonance images. Two areas were considered anatomically connected if they showed statistically significant correlations in cortical thickness and we constructed the network of such connections using 124 brains from the International Consortium for Brain Mapping database. Significant short- and long-range connections were found in both intra- and interhemispheric regions, many of which were consistent with known neuroanatomical pathways measured by human diffusion imaging. More importantly, we showed that the human brain anatomical network had robust small-world properties with cohesive neighborhoods and short mean distances between regions that were insensitive to the selection of correlation thresholds. Additionally, we also found that this network and the probability of finding a connection between 2 regions for a given anatomical distance had both exponentially truncated power-law distributions. Our results demonstrated the basic organizational principles for the anatomical network in the human brain compatible with previous functional networks studies, which provides important implications of how functional brain states originate from their structural underpinnings. To our knowledge, this study provides the first report of small-world properties and degree distribution of anatomical networks in the human brain using cortical thickness measurements.

Small-world anatomical networks in the human brain revealed by cortical thickness from MRI. Publishing Authors By Initials

Y He,ZJ Chen,AC Evans,

For similar nervous system: nerve net research abstracts see: nervous system: nerve net research

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Small-world anatomical networks in the human brain revealed by cortical thickness from MRI. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Cerebral cortex (New York, N.Y. : 1991)

VOLUME: 17

Page Numbers: 2407-19

Journal Abbreviation: Cereb. Cortex

ISSN: 1047-3211

DAY: 4

MONTH: 01

YEAR: 2007

Small-world anatomical networks in the human brain revealed by cortical thickness from MRI. Information

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LANGUAGE: eng

NlmUniqueID: 9110718

Small-world anatomical networks in the human brain revealed by cortical thickness from MRI. Keywords Mesh Terms:

KEYWORDS: Nerve Net

MESH TERMS: physiology

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Grant and Affiliation Information for Small-world anatomical networks in the human brain revealed by cortical thickness from MRI.

AFFILIATION: McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, 3801 University Street, Montreal, QC, Canada.

Country: United States

AGENCY: United States NIMH

GRANT: P01 MH 052176-11

ACRONYM: MH

MEDLINETA: Cereb Cortex

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