Small heat shock proteins protect against alpha-synuclein-induced toxicity and aggregation.

Small heat shock proteins protect against alpha-synuclein-induced toxicity and aggregation. Research Abstract Details 

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Small heat shock proteins protect against alpha-synuclein-induced toxicity and aggregation. Abstract Text:

Tiago Fleming Outeiro,Jochen Klucken,Katherine E Strathearn,Fang Liu,Paul Nguyen,Jean-Christophe Rochet,Bradley T Hyman,Pamela J McLean,Tiago Fleming Outeiro,Jochen Klucken,Katherine E Strathearn,Fang Liu,Paul Nguyen,Jean-Christophe Rochet,Bradley T Hyman,Pamela J McLean,

Protein misfolding and inclusion formation are common events in neurodegenerative diseases, such as Parkinson's disease (PD), Alzheimer's disease (AD) or Huntington's disease (HD). Alpha-synuclein (aSyn) is the main protein component of inclusions called Lewy bodies (LB) which are pathognomic of PD, Dementia with Lewy bodies (DLB), and other diseases collectively known as LB diseases. Heat shock proteins (HSPs) are one class of the cellular quality control system that mediate protein folding, remodeling, and even disaggregation. Here, we investigated the role of the small heat shock proteins Hsp27 and alphaB-crystallin, in LB diseases. We demonstrate, via quantitative PCR, that Hsp27 messenger RNA levels are approximately 2-3-fold higher in DLB cases compared to control. We also show a corresponding increase in Hsp27 protein levels. Furthermore, we found that Hsp27 reduces aSyn-induced toxicity by approximately 80% in a culture model while alphaB-crystallin reduces toxicity by approximately 20%. In addition, intracellular inclusions were immunopositive for endogenous Hsp27, and overexpression of this protein reduced aSyn aggregation in a cell culture model.

Small heat shock proteins protect against alpha-synuclein-induced toxicity and aggregation. Publishing Authors By Initials

TF Outeiro,J Klucken,KE Strathearn,F Liu,P Nguyen,JC Rochet,BT Hyman,PJ McLean,TF Outeiro,J Klucken,KE Strathearn,F Liu,P Nguyen,JC Rochet,BT Hyman,PJ McLean,

For similar proteins: nerve tissue proteins: synucleins: alpha-synuclein research abstracts see: proteins: nerve tissue proteins: synucleins: alpha-synuclein research

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Small heat shock proteins protect against alpha-synuclein-induced toxicity and aggregation. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Biochemical and biophysical research communication

VOLUME: 351

Page Numbers: 631-8

Journal Abbreviation: Biochem. Biophys. Res. Commun.

ISSN: 0006-291X

DAY: 26

MONTH: 10

YEAR: 2006

Small heat shock proteins protect against alpha-synuclein-induced toxicity and aggregation. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 372516

Small heat shock proteins protect against alpha-synuclein-induced toxicity and aggregation. Keywords Mesh Terms:

KEYWORDS: alpha-Synuclein

MESH TERMS: pharmacology

Chemical & Substance for Abstract: Small heat shock proteins protect against alpha-synuclein-induced toxicity and aggregation. Information

Substance Name: alpha-Synuclein

Registry Number: 0

Grant and Affiliation Information for Small heat shock proteins protect against alpha-synuclein-induced toxicity and aggregation.

AFFILIATION: Alzheimer's Research Unit, MassGeneral Institute for Neurodegenerative Disease, MGH, Harvard Medical School, Charlestown, MA 02129, USA. touteir@partners.org

Country: United States

AGENCY: United States NINDS

GRANT: R01-NS049221

ACRONYM: NS

MEDLINETA: Biochem Biophys Res Commun

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