Small GTP-binding proteins and mitogen-activated protein kinases as promising therapeutic targets of vascular remodeling.

Small GTP-binding proteins and mitogen-activated protein kinases as promising therapeutic targets of vascular remodeling. Research Abstract Details 

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Small GTP-binding proteins and mitogen-activated protein kinases as promising therapeutic targets of vascular remodeling. Abstract Text:

Heigoro Shirai,Michael Autieri,Satoru Eguchi,

PURPOSE OF REVIEW: To summarize the most recent findings concerning the targeting of mitogen-activated protein kinases and small GTP-binding proteins toward vascular remodeling together with molecular mechanisms of their activations in vascular pathophysiology. RECENT FINDINGS: In addition to targeting the classical Ras/extracellular signal-regulated kinase cascade, Rho-kinase inhibitors, as well as the HMG-CoA reductase inhibitors, or 'statins', have pleiotropic efficacy for experimental cardiovascular diseases that involve inhibition of the signal transduction cascades originated by the small GTP-binding proteins such as Rho and Rac. Moreover, the underlying molecular mechanisms of the activation of these small GTP-binding proteins and downstream mitogen-activated protein kinases in cardiovascular tissue and cells have recently been better characterized. Additionally, gene-targeting studies in animal models are revealing select roles of the isoforms of these signaling proteins in the pathophysiology of cardiovascular disease. This is exemplified by the role of c-Jun NH(2)-terminal kinases in mediating atherosclerosis and diabetes. SUMMARY: Characterization of the function of small GTP-binding proteins, mitogen-activated protein kinases and their effectors in cardiovascular pathophysiology can be readily identified by using select inhibitors, dominant-negative gene transfer and the generation of select gene-targeted animals. These findings strongly support the notion that small GTP-binding proteins and mitogen-activated protein kinases are promising therapeutic targets toward cardiovascular diseases.

Small GTP-binding proteins and mitogen-activated protein kinases as promising therapeutic targets of vascular remodeling. Publishing Authors By Initials

H Shirai,M Autieri,S Eguchi,

For similar enzymes and coenzymes: enzymes: transferases: phosphotransferases: phosphotransferases (alcohol group acceptor): protein kinases: protein-serine-threonine kinases: mitogen-activated protein kinases: p38 mitogen-activated protein kinases research abstracts see: enzymes and coenzymes: enzymes: transferases: phosphotransferases: phosphotransferases (alcohol group acceptor): protein kinases: protein-serine-threonine kinases: mitogen-activated protein kinases: p38 mitogen-activated protein kinases research

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Small GTP-binding proteins and mitogen-activated protein kinases as promising therapeutic targets of vascular remodeling. Journal Published:

PUBLICATION TYPE: Review

Journal: Current opinion in nephrology and hypertension

VOLUME: 16

Page Numbers: 111-5

Journal Abbreviation: Curr. Opin. Nephrol. Hypertens

ISSN: 1062-4821

DAY: 3

MONTH: Mar

YEAR: 2007

Small GTP-binding proteins and mitogen-activated protein kinases as promising therapeutic targets of vascular remodeling. Information

Number of References: 37

LANGUAGE: eng

NlmUniqueID: 9303753

Small GTP-binding proteins and mitogen-activated protein kinases as promising therapeutic targets of vascular remodeling. Keywords Mesh Terms:

KEYWORDS: p38 Mitogen-Activated Protein Kinases

MESH TERMS: physiology

Chemical & Substance for Abstract: Small GTP-binding proteins and mitogen-activated protein kinases as promising therapeutic targets of vascular remodeling. Information

Substance Name: GTP-Binding Proteins

Registry Number: EC 3.6.1.-

Grant and Affiliation Information for Small GTP-binding proteins and mitogen-activated protein kinases as promising therapeutic targets of vascular remodeling.

AFFILIATION: Cardiovascular Research Center and Department of Physiology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA.

Country: England

AGENCY: United States NHLBI

GRANT: HL076770

ACRONYM: HL

MEDLINETA: Curr Opin Nephrol Hypertens

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