Small animal absorbed radiation dose from serial micro-computed tomography imaging.

Small animal absorbed radiation dose from serial micro-computed tomography imaging. Research Abstract Details 

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Small animal absorbed radiation dose from serial micro-computed tomography imaging. Abstract Text:

Stephanie K Carlson,Kelly L Classic,Claire E Bender,Stephen J Russell,

PURPOSE: To determine the radiation dose to mouse cancer xenografts from serial micro-computed tomography (CT) examinations. PROCEDURES: A nude mouse with a 15-mm subcutaneous pancreatic cancer xenograft in the rightflank was used. Radiation exposure to the subcutaneous tumor and the mouse pancreas (to simulate an orthotopic pancreatic tumor model) was measured using lithium fluoride thermoluminescent dosimeters. Ultrafast micro-CT was performed using 80 kVp, 0.26 mA, 0.156 mm slice thickness, 256 slices, 0.7 mm Al filtration, and 60-second image acquisition time (15 mA second). Micro-CT imaging acquisitions were repeated four times. RESULTS: We measured consistently low tumor doses (0.014 to 0.02 Gy; average=0.017 Gy) per scan. Orthotopic doses in the region of the pancreas were also consistently low (0.014 to 0.018 Gy; average=0.016 Gy) per scan. CONCLUSIONS: Radiation doses delivered during ultrafast micro-CT serial imaging in the mouse are low and are likely below the threshold to affect tumor growth.

Small animal absorbed radiation dose from serial micro-computed tomography imaging. Publishing Authors By Initials

SK Carlson,KL Classic,CE Bender,SJ Russell,

For similar surgical procedures, operative: transplantation: transplantation, heterologous research abstracts see: surgical procedures, operative: transplantation: transplantation, heterologous research

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Small animal absorbed radiation dose from serial micro-computed tomography imaging. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Molecular imaging and biology : MIB : the official

VOLUME: 9

Page Numbers: 78-82

Journal Abbreviation:

ISSN: 1536-1632

DAY: 3

MONTH: 12

YEAR: 2007

Small animal absorbed radiation dose from serial micro-computed tomography imaging. Information

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LANGUAGE: eng

NlmUniqueID: 101125610

Small animal absorbed radiation dose from serial micro-computed tomography imaging. Keywords Mesh Terms:

KEYWORDS: Transplantation, Heterologous

MESH TERMS: methods

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Grant and Affiliation Information for Small animal absorbed radiation dose from serial micro-computed tomography imaging.

AFFILIATION: Department of Radiology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA. scarlson@mayo.edu

Country: United States

AGENCY: United States NCI

GRANT: R01 CA100634

ACRONYM: CA

MEDLINETA: Mol Imaging Biol

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