Smad3 and NFAT cooperate to induce Foxp3 expression through its enhancer.

Smad3 and NFAT cooperate to induce Foxp3 expression through its enhancer. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Smad3 and NFAT cooperate to induce Foxp3 expression through its enhancer. Abstract Text:

Yukiko Tone,Keiji Furuuchi,Yoshitsugu Kojima,Mark L Tykocinski,Mark I Greene,Masahide Tone,

The transcription factor Foxp3 is involved in the differentiation, function and survival of CD4+CD25+ regulatory T (T(reg)) cells. Details of the mechanism underlying the induction of Foxp3 expression remain unknown, because studies of the transcriptional regulation of the Foxp3 gene are limited by the small number of T(reg) cells in mononuclear cell populations. Here we have generated a model system for analyzing Foxp3 induction and, by using this system with primary T cells, we have identified an enhancer element in this gene. The transcription factors Smad3 and NFAT are required for activity of this Foxp3 enhancer, and both factors are essential for histone acetylation in the enhancer region and induction of Foxp3. These biochemical properties that define Foxp3 expression explain many of the effects of transforming growth factor-beta on the function of Foxp3+ T(reg) cells.

Smad3 and NFAT cooperate to induce Foxp3 expression through its enhancer. Publishing Authors By Initials

Y Tone,K Furuuchi,Y Kojima,ML Tykocinski,MI Greene,M Tone,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Smad3 and NFAT cooperate to induce Foxp3 expression through its enhancer. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Nature immunology

VOLUME: 9

Page Numbers: 194-202

Journal Abbreviation: Nat. Immunol.

ISSN: 1529-2916

DAY: 23

MONTH: 12

YEAR: 2007

Smad3 and NFAT cooperate to induce Foxp3 expression through its enhancer. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 100941354

Smad3 and NFAT cooperate to induce Foxp3 expression through its enhancer. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Smad3 and NFAT cooperate to induce Foxp3 expression through its enhancer. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Smad3 and NFAT cooperate to induce Foxp3 expression through its enhancer.

AFFILIATION: Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Nat Immunol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Smad3 and NFAT cooperate to induce Foxp3 expression through its enhancer Related Publications

• Differential expression of 12 histone deacetylase (HDAC) genes in astrocytomas and normal brain tissue: class II and IV are hypoexpressed in glioblastomas.
• Differential expression of E-cadherin gene in human neuroepithelial tumors.
• Drug-resistance in central nervous system tumors: from the traditional cell-resistance model to the genetically driven approaches on therapy.
• Fungal infection by Paracoccidioides brasiliensis mimicking bone tumor.
• Gene expression profile analysis of primary glioblastomas and non-neoplastic brain tissue: identification of potential target genes by oligonucleotide microarray and real-time quantitative PCR.
• Insertion (15;14)(q22;q13q32) in a case of Ph+ ALL.
• OX40 gene expression is up-regulated by chromatin remodeling in its promoter region containing Sp1/Sp3, YY1, and NF-kappa B binding sites.
• Quantitative PCR analysis of the expression profile of genes related to multiple drug resistance in tumors of the central nervous system.
• Smad3 and NFAT cooperate to induce Foxp3 expression through its enhancer.