Slow human immunodeficiency virus type 1 evolution in viral reservoirs in infants treated with effective antiretroviral therapy.

Slow human immunodeficiency virus type 1 evolution in viral reservoirs in infants treated with effective antiretroviral therapy. Research Abstract Details 

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Slow human immunodeficiency virus type 1 evolution in viral reservoirs in infants treated with effective antiretroviral therapy. Abstract Text:

Deborah Persaud,Stuart C Ray,Joleen Kajdas,Aima Ahonkhai,George K Siberry,Kimberly Ferguson,Carrie Ziemniak,Thomas C Quinn,Joseph P Casazza,Steven Zeichner,Stephen J Gange,Douglas C Watson,

A longitudinal study of viral reservoirs in children initiating highly active antiretroviral therapy (HAART) in early infancy was undertaken to test the hypothesis that early effective treatment affects the persistence of replication-competent viral latency and the evolution of HIV-1 in resting CD4(+) T cells. An end point dilution culture assay was used to measure the frequencies of latently-infected resting CD4(+) T cells harboring replication-competent virus in early and late treated children. Gag, pol, and env also were sequenced and compared to pretreatment sequences. HIV-1-specific humoral and cellular immune responses were also assessed. Blood samples were obtained from 12 HIV-1-infected children who started HAART at a median of 1.9 months of age and who maintained suppression of HIV-1 replication for up to 5.5 years. Replication-competent HIV-1 was recovered from 10/12 (84%) subjects. Evolution in gag, pol, and env was restricted for years in early-treated children. HAART initiated from early infancy does not prevent the establishment of a reservoir of latent provirus, but does significantly limit the evolution of HIV-1 in viral reservoirs. The effect of early therapy on HIV-1 evolution may have implications for long-term pharmacologic control of HIV-1.

Slow human immunodeficiency virus type 1 evolution in viral reservoirs in infants treated with effective antiretroviral therapy. Publishing Authors By Initials

D Persaud,SC Ray,J Kajdas,A Ahonkhai,GK Siberry,K Ferguson,C Ziemniak,TC Quinn,JP Casazza,S Zeichner,SJ Gange,DC Watson,

For similar biological phenomena, cell phenomena, and immunity: biological phenomena: microbiologic phenomena: viral physiology: virus replication research abstracts see: biological phenomena, cell phenomena, and immunity: biological phenomena: microbiologic phenomena: viral physiology: virus replication research

PUBMED ID PMID:

MEDLINE DATE:

Slow human immunodeficiency virus type 1 evolution in viral reservoirs in infants treated with effective antiretroviral therapy. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: AIDS research and human retroviruses

VOLUME: 23

Page Numbers: 381-90

Journal Abbreviation:

ISSN: 0889-2229

DAY: 3

MONTH: Mar

YEAR: 2007

Slow human immunodeficiency virus type 1 evolution in viral reservoirs in infants treated with effective antiretroviral therapy. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8709376

Slow human immunodeficiency virus type 1 evolution in viral reservoirs in infants treated with effective antiretroviral therapy. Keywords Mesh Terms:

KEYWORDS: Virus Replication

MESH TERMS: physiology

Chemical & Substance for Abstract: Slow human immunodeficiency virus type 1 evolution in viral reservoirs in infants treated with effective antiretroviral therapy. Information

Substance Name: RNA, Viral

Registry Number: 0

Grant and Affiliation Information for Slow human immunodeficiency virus type 1 evolution in viral reservoirs in infants treated with effective antiretroviral therapy.

AFFILIATION: Department of Pediatrics and Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.

Country: United States

AGENCY: United States NIAID

GRANT: R01 AI 055312

ACRONYM: AI

MEDLINETA: AIDS Res Hum Retroviruses

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