Slow clearance of measles virus RNA after acute infection.

Slow clearance of measles virus RNA after acute infection. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Slow clearance of measles virus RNA after acute infection. Abstract Text:

Michaela A Riddell,William J Moss,Debra Hauer,Mwaka Monze,Diane E Griffin,

BACKGROUND: Measles virus (MV) RNA was detected 1 month after hospitalization with measles in more than half of Zambian children but the duration of detectable RNA was not determined. OBJECTIVES: To characterize the time course of MV clearance and identify factors associated with presence of viral RNA at late times after clinical recovery from infection. STUDY DESIGN: Blood, urine and nasopharyngeal specimens from 49 Zambian children with laboratory-confirmed measles were collected a median of 100 days (range 65-118) after rash onset. Samples were assayed for MV nucleocapsid and hemagglutinin RNA by reverse transcriptase-polymerase chain reaction. Amplified products were sequenced. Selected immunologic studies were performed. RESULTS: MV RNA was detected in at least one specimen from 18 children (37%). Eighteen percent of 44 blood mononuclear cell, 23% of 30 nasopharyngeal and 50% of 6 urine specimens were positive. Detection was not associated with HIV-1 infection, % CD4(+) T lymphocytes, plasma interleukin-10 levels or persistent MV-specific IgM. The MV genotype was D2 and sequences of late specimens were the same as specimens collected during acute illness. CONCLUSIONS: Presence of viral RNA at multiple sites more than 3 months after acute disease suggests that clearance of MV-infected cells occurs over many months.

Slow clearance of measles virus RNA after acute infection. Publishing Authors By Initials

MA Riddell,WJ Moss,D Hauer,M Monze,DE Griffin,

For similar geographic locations: africa: africa south of the sahara: africa, southern: zambia research abstracts see: geographic locations: africa: africa south of the sahara: africa, southern: zambia research

PUBMED ID PMID:

MEDLINE DATE:

Slow clearance of measles virus RNA after acute infection. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of clinical virology : the official public

VOLUME: 39

Page Numbers: 312-7

Journal Abbreviation: J. Clin. Virol.

ISSN: 1386-6532

DAY: 10

MONTH: 07

YEAR: 2007

Slow clearance of measles virus RNA after acute infection. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9815671

Slow clearance of measles virus RNA after acute infection. Keywords Mesh Terms:

KEYWORDS: Zambia

MESH TERMS: blood

Chemical & Substance for Abstract: Slow clearance of measles virus RNA after acute infection. Information

Substance Name: RNA, Viral

Registry Number: 0

Grant and Affiliation Information for Slow clearance of measles virus RNA after acute infection.

AFFILIATION: W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, 615 N. Wolfe Street, Baltimore, MD 21205, USA.

Country: Netherlands

AGENCY: United States NIAID

GRANT: AI23047

ACRONYM: AI

MEDLINETA: J Clin Virol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Slow clearance of measles virus RNA after acute infection Related Publications

• A field-sweep/field-lock system for superconducting magnets--Application to high-field EPR.
• Acid sphingomyelinase deficiency increases susceptibility to fatal alphavirus encephalomyelitis.
• Commercial aspects of bovine embryo transfer.
• Comparison of low versus high tacrolimus levels in kidney transplantation: assessment of efficacy by protocol biopsies.
• Description of depolarization effects in double-quantum solid state nuclear magnetic resonance experiments using multipole-multimode Floquet theory.
• Dynamic nuclear polarization of amyloidogenic peptide nanocrystals: GNNQQNY, a core segment of the yeast prion protein Sup35p.
• Effects of PKC412, nilotinib, and imatinib against GIST-associated PDGFRA mutants with differential imatinib sensitivity.
• Equine fetal kinetics: Presentation and location.
• Eye movement, vection, and motion sickness with foveal and peripheral vision.
• Hemagglutinin protein is a primary target of the measles virus-specific HLA-A2-restricted CD8+ T cell response during measles and after vaccination.
• High-density lipoprotein and the risk of recurrent venous thromboembolism.
• High-frequency dynamic nuclear polarization using mixtures of TEMPO and trityl radicals.
• Identification of carbonylated proteins from enriched rat skeletal muscle mitochondria using affinity chromatography-stable isotope labeling and tandem mass spectrometry.
• In situ temperature jump high-frequency dynamic nuclear polarization experiments: enhanced sensitivity in liquid-state NMR spectroscopy.
• Incidence of invasive pneumococcal disease among individuals with sickle cell disease before and after the introduction of the pneumococcal conjugate vaccine.
• Increasing Stimulation Frequency Prolongs Force Output in Healthy Thenar Muscle: 1923: Board #211 10:30 AM- 10:30 AM.
• Interpreting treatment effects when cases are institutionalized after treatment.
• Intrinsic stability and functional properties of disulfide bond-stabilized coagulation factor VIIIa variants.
• Multipole-multimode Floquet theory of rotational resonance width experiments: 13C-13C distance measurements in uniformly labeled solids.
• Natural outcome and ultrasonic identification of equine fetal twins.
• Preparative peptide isoelectric focusing as a tool for improving the identification of lysine-acetylated peptides from complex mixtures.
• Proteomic mapping of 4-hydroxynonenal protein modification sites by solid-phase hydrazide chemistry and mass spectrometry.
• Proton assisted insensitive nuclei cross polarization.
• Recovery and transfer of equine embryos.
• Resident dendritic cells are the predominant TNF-secreting cell in early renal ischemia-reperfusion injury.
• Sindbis virus entry into cells triggers apoptosis by activating sphingomyelinase, leading to the release of ceramide.
• Spontaneously reduced blood pressure load in the rat streptozotocin-induced diabetes model: potential pathogenetic relevance.
• Sustaining knowledge transfer through leadership.
• Synergistic roles of antibody and interferon in noncytolytic clearance of Sindbis virus from different regions of the central nervous system.
• TOTAPOL: a biradical polarizing agent for dynamic nuclear polarization experiments in aqueous media.