Sle3 and Sle5 can independently couple with Sle1 to mediate severe lupus nephritis.

Sle3 and Sle5 can independently couple with Sle1 to mediate severe lupus nephritis. Research Abstract Details 

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Sle3 and Sle5 can independently couple with Sle1 to mediate severe lupus nephritis. Abstract Text:

K Liu,Q Z Li,Y Yu,C Liang,S Subramanian,Z Zeng,H W Wang,C Xie,X J Zhou,C Mohan,E K Wakeland,K Liu,Q Z Li,Y Yu,C Liang,S Subramanian,Z Zeng,H W Wang,C Xie,X J Zhou,C Mohan,E K Wakeland,K Liu,Q Z Li,Y Yu,C Liang,S Subramanian,Z Zeng,H W Wang,C Xie,X J Zhou,C Mohan,E K Wakeland,

Genetic analyses of the lupus-prone NZM2410 mouse have identified multiple susceptibility loci on chromosome 7, termed Sle3 and Sle5. Both of these loci were contained within a large congenic interval, originally termed as Sle3 that strongly impacts a variety of myeloid and T-cell phenotypes and mediates fatal lupus nephritis when combined with Sle1. We have now produced two subcongenic strains, B6.Sle3 and B6.Sle5, carrying the Sle3 and Sle5 intervals separately and characterized their phenotypes as monocongenic strains and individually in combination with Sle1. Neither B6.Sle3 nor B6.Sle5 monocongenic strain develop severe autoimmunity; however, both of these intervals cause the development of severe glomerulonephritis when combined with Sle1. Thus, B6.Sle1Sle3 and B6.Sle1Sle5 exhibit splenomegaly, expansion of activated B and CD4+ T-cell populations and high levels of IgG and IgM autoantibodies targeting multiple nuclear antigens, intact glomeruli and various other autoantigens. In addition, B6.Sle1Sle3 mice also produced higher levels of IgA antinuclear autoantibodies, which were implicated in the development of IgA nephropathy. Our results indicate that Sle3 and Sle5 can independently complement with Sle1, through shared and unique mechanisms, to mediate the development of severe autoimmunity.

Sle3 and Sle5 can independently couple with Sle1 to mediate severe lupus nephritis. Publishing Authors By Initials

K Liu,QZ Li,Y Yu,C Liang,S Subramanian,Z Zeng,HW Wang,C Xie,XJ Zhou,C Mohan,EK Wakeland,K Liu,QZ Li,Y Yu,C Liang,S Subramanian,Z Zeng,HW Wang,C Xie,XJ Zhou,C Mohan,EK Wakeland,K Liu,QZ Li,Y Yu,C Liang,S Subramanian,Z Zeng,HW Wang,C Xie,XJ Zhou,C Mohan,EK Wakeland,

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Sle3 and Sle5 can independently couple with Sle1 to mediate severe lupus nephritis. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Genes and immunity

VOLUME: 8

Page Numbers: 634-45

Journal Abbreviation: Genes Immun.

ISSN: 1466-4879

DAY: 30

MONTH: 08

YEAR: 2007

Sle3 and Sle5 can independently couple with Sle1 to mediate severe lupus nephritis. Information

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LANGUAGE: eng

NlmUniqueID: 100953417

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Grant and Affiliation Information for Sle3 and Sle5 can independently couple with Sle1 to mediate severe lupus nephritis.

AFFILIATION: Department of Immunology, The University of Texas Southwestern Medical Center, Dallas, TX 75390-9093, USA. kui.liu@utsouthwestern.edu

Country: England

AGENCY: United States NIAID

GRANT: P01 AI 39824

ACRONYM: AI

MEDLINETA: Genes Immun

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