SLC26 chloride/base exchangers in the kidney in health and disease.

SLC26 chloride/base exchangers in the kidney in health and disease. Research Abstract Details 

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SLC26 chloride/base exchangers in the kidney in health and disease. Abstract Text:

Manoocher Soleimani,Jie Xu,

Solute-linked carrier 26 (SLC26) isoforms are members of a large, conserved family of anion exchangers, many of which display highly restricted and distinct tissue distribution. Cloning experiments have identified 10 SLC26 genes or isoforms (SLC26A1-11). Except for SLC26A5 (prestin), all function as anion exchangers with versatility with respect to transported anions. Modes of transport mediated by SLC26 members include the exchange of chloride for bicarbonate, hydroxyl, sulfate, formate, iodide, or oxalate with variable specificity. Other anion exchange modes not involving chloride also have been reported for some of the members of this family. Several members of SLC26 isoforms are expressed in the kidney. These include SLC26A1 (SAT1), SLC26A4 (pendrin), SLC26A6 (putative anion transporter [PAT1] or chloride/formate exchange [CFEX]), SLC26A7, and SLC26A11. Each isoform displays a specific nephron segment distribution with a distinct subcellular localization. Coupled to expression studies and examination of genetically engineered mice deficient in various SLC26 isoforms, the evolving picture points to important roles for the SLC26 family in chloride absorption, vascular volume homeostasis, acid-base regulation, and oxalate excretion in the kidney. This review summarizes recent advances in the identification and characterization of SLC26 family members, with specific emphasis on their distribution and role in kidney physiology. Specifically, the roles of A4 (pendrin), A6 (PAT1), and A7 (PAT2) in chloride homeostasis, oxalate excretion, and acid-base balance are discussed.

SLC26 chloride/base exchangers in the kidney in health and disease. Publishing Authors By Initials

M Soleimani,J Xu,

For similar proteins: protein isoforms research abstracts see: proteins: protein isoforms research

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SLC26 chloride/base exchangers in the kidney in health and disease. Journal Published:

PUBLICATION TYPE: Review

Journal: Seminars in nephrology

VOLUME: 26

Page Numbers: 375-85

Journal Abbreviation: Semin. Nephrol.

ISSN: 0270-9295

DAY: 3

MONTH: Sep

YEAR: 2006

SLC26 chloride/base exchangers in the kidney in health and disease. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8110298

SLC26 chloride/base exchangers in the kidney in health and disease. Keywords Mesh Terms:

KEYWORDS: Protein Isoforms

MESH TERMS: metabolism

Chemical & Substance for Abstract: SLC26 chloride/base exchangers in the kidney in health and disease. Information

Substance Name: SLC26A4 protein, human

Registry Number: 0

Grant and Affiliation Information for SLC26 chloride/base exchangers in the kidney in health and disease.

AFFILIATION: Division of Nephrology and Hypertension, Department of Medicine, University of Cincinnati, 231 Albert Sabin Way, Cincinnati, OH 45267, USA. manoocher.soleimani@uc.edu

Country: United States

AGENCY: United States NIDDK

GRANT: R01 DK 54430

ACRONYM: DK

MEDLINETA: Semin Nephrol

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