Ski represses bone morphogenic protein signaling in Xenopus and mammalian cells.

Ski represses bone morphogenic protein signaling in Xenopus and mammalian cells. Research Abstract Details 

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Ski represses bone morphogenic protein signaling in Xenopus and mammalian cells. Abstract Text:

W Wang,F V Mariani,R M Harland,K Luo,

The bone morphogenic proteins (BMPs) play important roles in vertebrate development. In Xenopus, BMPs act as epidermal inducers and also as negative regulators of neurogenesis. Antagonism of BMP signaling results in neuralization. BMPs signal through the cell-surface receptors and downstream Smad molecules. Upon stimulation with BMP, Smad1, Smad5, and Smad8 are phosphorylated by the activated BMP receptors, form a complex with Smad4, and translocate into the nucleus, where they regulate the expression of BMP target genes. Here, we show that the Ski oncoprotein can block BMP signaling and the expression of BMP-responsive genes in both Xenopus and mammalian cells by directly interacting with and repressing the activity of BMP-specific Smad complexes. This ability to antagonize BMP signaling results in neuralization by Ski in the Xenopus embryo and blocking of osteoblast differentiation of murine W-20-17 cells. Thus, Ski is able to repress the activity of all receptor-associated Smads and may regulate vertebrate development by modulating the signaling activity of transforming growth factor-beta family members.

Ski represses bone morphogenic protein signaling in Xenopus and mammalian cells. Publishing Authors By Initials

W Wang,FV Mariani,RM Harland,K Luo,

For similar animals: chordata: vertebrates: amphibia: anura: pipidae: xenopus: xenopus laevis research abstracts see: animals: chordata: vertebrates: amphibia: anura: pipidae: xenopus: xenopus laevis research

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MEDLINE DATE:

Ski represses bone morphogenic protein signaling in Xenopus and mammalian cells. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Proceedings of the National Academy of Sciences of

VOLUME: 97

Page Numbers: 14394-9

Journal Abbreviation: Proc. Natl. Acad. Sci. U.S.A.

ISSN: 0027-8424

DAY: 19

MONTH: Dec

YEAR: 2000

Ski represses bone morphogenic protein signaling in Xenopus and mammalian cells. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7505876

Ski represses bone morphogenic protein signaling in Xenopus and mammalian cells. Keywords Mesh Terms:

KEYWORDS: Xenopus laevis

MESH TERMS: metabolism

Chemical & Substance for Abstract: Ski represses bone morphogenic protein signaling in Xenopus and mammalian cells. Information

Substance Name: SKI protein, human

Registry Number: 126648-96-2

Grant and Affiliation Information for Ski represses bone morphogenic protein signaling in Xenopus and mammalian cells.

AFFILIATION: Life Sciences Division, Lawrence Berkeley National Laboratory, and Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA.

Country: UNITED STATES

AGENCY: United States NIGMS

GRANT: GM49346

ACRONYM: GM

MEDLINETA: Proc Natl Acad Sci U S A

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