Skeletal overexpression of connective tissue growth factor impairs bone formation and causes osteopenia.

Skeletal overexpression of connective tissue growth factor impairs bone formation and causes osteopenia. Research Abstract Details 

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Skeletal overexpression of connective tissue growth factor impairs bone formation and causes osteopenia. Abstract Text:

Connective tissue growth factor (CTGF), a member of the CCN family of proteins, is expressed in skeletal cells, and the ctgf null mutation leads to neonatal lethality due to defects in skeletal development. To define the function of CTGF in the postnatal skeleton, we created transgenic mice overexpressing CTGF under the control of the human osteocalcin promoter. CTGF transgenic female and male mice exhibited a significant decrease in bone mineral density, compared with wild-type littermate controls. Bone histomorphometry revealed that CTGF overexpression caused decreased trabecular bone volume due to impaired osteoblastic activity because mineral apposition and bone formation rates were decreased. Osteoblast and osteoclast number and bone resorption were not altered. Calvarial osteoblasts and stromal cells from CTGF transgenics displayed decreased alkaline phosphatase and osteocalcin mRNA levels and reduced bone morphogenetic protein (BMP) signaling mothers against decapentaplegic, Wnt/beta-catenin, and IGF-I/Akt signaling. In conclusion, CTGF overexpression in vivo causes osteopenia, secondary to decreased bone formation, possibly by antagonizing BMP, Wnt, and IGF-I signaling and activity.

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Skeletal overexpression of connective tissue growth factor impairs bone formation and causes osteopenia. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Endocrinology

VOLUME: 149

Page Numbers: 4374-81

Journal Abbreviation: Endocrinology

ISSN: 0013-7227

DAY: 5

MONTH: 06

YEAR: 2008

Skeletal overexpression of connective tissue growth factor impairs bone formation and causes osteopenia. Information

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LANGUAGE: eng

NlmUniqueID: 375040

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Grant and Affiliation Information for Skeletal overexpression of connective tissue growth factor impairs bone formation and causes osteopenia.

AFFILIATION: Department of Research, Saint Francis Hospital and Medical Center, 114 Woodland Street, Hartford, Connecticut 06105-1299. ecanalis@stfranciscare.org.

Country: United States

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MEDLINETA: Endocrinology

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