Skeletal muscle fiber-type switching, exercise intolerance, and myopathy in PGC-1alpha muscle-specific knock-out animals.

Skeletal muscle fiber-type switching, exercise intolerance, and myopathy in PGC-1alpha muscle-specific knock-out animals. Research Abstract Details 

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Skeletal muscle fiber-type switching, exercise intolerance, and myopathy in PGC-1alpha muscle-specific knock-out animals. Abstract Text:

Christoph Handschin,Sherry Chin,Ping Li,Fenfen Liu,Eleftheria Maratos-Flier,Nathan K Lebrasseur,Zhen Yan,Bruce M Spiegelman,Christoph Handschin,Sherry Chin,Ping Li,Fenfen Liu,Eleftheria Maratos-Flier,Nathan K Lebrasseur,Zhen Yan,Bruce M Spiegelman,

The transcriptional coactivator peroxisome proliferator-activated receptor gamma coactivator 1alpha (PGC-1alpha) is a key integrator of neuromuscular activity in skeletal muscle. Ectopic expression of PGC-1alpha in muscle results in increased mitochondrial number and function as well as an increase in oxidative, fatigue-resistant muscle fibers. Whole body PGC-1alpha knock-out mice have a very complex phenotype but do not have a marked skeletal muscle phenotype. We thus analyzed skeletal muscle-specific PGC-1alpha knock-out mice to identify a specific role for PGC-1alpha in skeletal muscle function. These mice exhibit a shift from oxidative type I and IIa toward type IIx and IIb muscle fibers. Moreover, skeletal muscle-specific PGC-1alpha knock-out animals have reduced endurance capacity and exhibit fiber damage and elevated markers of inflammation following treadmill running. Our data demonstrate a critical role for PGC-1alpha in maintenance of normal fiber type composition and of muscle fiber integrity following exertion.

Skeletal muscle fiber-type switching, exercise intolerance, and myopathy in PGC-1alpha muscle-specific knock-out animals. Publishing Authors By Initials

C Handschin,S Chin,P Li,F Liu,E Maratos-Flier,NK Lebrasseur,Z Yan,BM Spiegelman,C Handschin,S Chin,P Li,F Liu,E Maratos-Flier,NK Lebrasseur,Z Yan,BM Spiegelman,

For similar proteins: transcription factors research abstracts see: proteins: transcription factors research

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Skeletal muscle fiber-type switching, exercise intolerance, and myopathy in PGC-1alpha muscle-specific knock-out animals. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The Journal of biological chemistry

VOLUME: 282

Page Numbers: 30014-21

Journal Abbreviation: J. Biol. Chem.

ISSN: 0021-9258

DAY: 16

MONTH: 08

YEAR: 2007

Skeletal muscle fiber-type switching, exercise intolerance, and myopathy in PGC-1alpha muscle-specific knock-out animals. Information

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LANGUAGE: eng

NlmUniqueID: 2985121

Skeletal muscle fiber-type switching, exercise intolerance, and myopathy in PGC-1alpha muscle-specific knock-out animals. Keywords Mesh Terms:

KEYWORDS: Transcription Factors

MESH TERMS: biosynthesis

Chemical & Substance for Abstract: Skeletal muscle fiber-type switching, exercise intolerance, and myopathy in PGC-1alpha muscle-specific knock-out animals. Information

Substance Name: Oxygen

Registry Number: 7782-44-7

Grant and Affiliation Information for Skeletal muscle fiber-type switching, exercise intolerance, and myopathy in PGC-1alpha muscle-specific knock-out animals.

AFFILIATION: Dana-Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA.

Country: United States

AGENCY: United States NIDDK

GRANT: DK61562

ACRONYM: DK

MEDLINETA: J Biol Chem

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