Sjörgren's syndrome treated with bromhexine: a randomised clinical study.

Sjörgren's syndrome treated with bromhexine: a randomised clinical study. Research Abstract Details 

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Sjörgren's syndrome treated with bromhexine: a randomised clinical study. Abstract Text:

Existing treatment for Sjögren's syndrome is unsatisfactory, and uncontrolled observations have suggested that bromhexine may be effective. Twenty-nine patients with Sjögren's syndrome were therefore assigned to two randomised double-blind crossover trials with bromhexine and placebo, each comprising two two-week periods. In the first trial bromhexine 24 mg/day was given by mouth; in the second the dose was increased to 48 mg/day. After each treatment period the Schirmer test response, break-up time, Bijsterveld score, and the time taken for the patient to eat a dry biscuit were recorded, as well as the patient's estimate of moistness in the eyes and mouth. In the second (higher-dose) trial values on the Schirmer test were significantly higher after bromhexine than after placebo and the break-up time was also increased after bromhexine, which suggested that the drug has a dose-dependent effect on lacrimal gland secretion in Sjögren's syndrome. It had no effect on salivary gland function. Bromhexine is therefore valuable in the treatment of Sjögren's syndrome.

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Sjörgren's syndrome treated with bromhexine: a randomised clinical study. Journal Published:

PUBLICATION TYPE: Randomized Controlled Trial

Journal: British medical journal

VOLUME: 1

Page Numbers: 1579-81

Journal Abbreviation: Br Med J

ISSN: 0007-1447

DAY: 17

MONTH: Jun

YEAR: 1978

Sjörgren's syndrome treated with bromhexine: a randomised clinical study. Information

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LANGUAGE: eng

NlmUniqueID: 372673

Sjörgren's syndrome treated with bromhexine: a randomised clinical study. Keywords Mesh Terms:

KEYWORDS: Sjogren's Syndrome

MESH TERMS: drug therapy

Chemical & Substance for Abstract: Sjörgren's syndrome treated with bromhexine: a randomised clinical study. Information

Substance Name: Bromhexine

Registry Number: 3572-43-8

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Country: ENGLAND

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MEDLINETA: Br Med J

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