Sjögren's syndrome (SjS)-like disease of mice: the importance of B lymphocytes and autoantibodies.

Sjögren's syndrome (SjS)-like disease of mice: the importance of B lymphocytes and autoantibodies. Research Abstract Details 

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Sjögren's syndrome (SjS)-like disease of mice: the importance of B lymphocytes and autoantibodies. Abstract Text:

Cuong Quoc Nguyen,Seunghee Ro Cha,Ammon Broughton Peck,

Sjögren's syndrome (SjS) is a systemic autoimmune disease in which an immunological attack against the salivary and lacrimal glands results, respectively, in severe dry mouth and dry eye diseases. Although a CD4+ T lymphocyte population is an integral component in the pathogenesis of SjS, recent studies have focused on the importance the B lymphocyte plays in both the pre-clinical and clinical phases of the disease process. To understand the molecular and cellular mechanisms involved in SjS, numerous mouse models that mimic major clinical manifestations of the human disease have been developed. Studies have begun to define the genetics, the nature of the autoimmune response towards the salivary and lacrimal glands, as well as the possible mechanisms for effecting glandular dysfunction, thereby establishing insights to new intervention therapies. Not surprising, the B cell is taking center stage. Here, we present an in-depth discussion of how B cell populations may be involved in orchestrating or determining exocrine gland dysfunction.

Sjögren's syndrome (SjS)-like disease of mice: the importance of B lymphocytes and autoantibodies. Publishing Authors By Initials

CQ Nguyen,SR Cha,AB Peck,

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Sjögren's syndrome (SjS)-like disease of mice: the importance of B lymphocytes and autoantibodies. Journal Published:

PUBLICATION TYPE: Review

Journal: Frontiers in bioscience : a journal and virtual li

VOLUME: 12

Page Numbers: 1767-89

Journal Abbreviation: Front. Biosci.

ISSN: 1093-4715

DAY: 1

MONTH: 01

YEAR: 2007

Sjögren's syndrome (SjS)-like disease of mice: the importance of B lymphocytes and autoantibodies. Information

Number of References: 216

LANGUAGE: eng

NlmUniqueID: 9709506

Sjögren's syndrome (SjS)-like disease of mice: the importance of B lymphocytes and autoantibodies. Keywords Mesh Terms:

KEYWORDS: Sjogren's Syndrome

MESH TERMS: immunology

Chemical & Substance for Abstract: Sjögren's syndrome (SjS)-like disease of mice: the importance of B lymphocytes and autoantibodies. Information

Substance Name: Interleukin-4

Registry Number: 207137-56-2

Grant and Affiliation Information for Sjögren's syndrome (SjS)-like disease of mice: the importance of B lymphocytes and autoantibodies.

AFFILIATION: University of Florida, College of Dentistry, Department of Oral Biology, PO Box 100424, Gainesville, FL 32610, USA, nguyen@pathology.ufl.edu

Country: United States

AGENCY: United States NIDCR

GRANT: DE55304

ACRONYM: DE

MEDLINETA: Front Biosci

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