Size at birth and autonomic function during psychological stress.

Size at birth and autonomic function during psychological stress. Research Abstract Details 

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Size at birth and autonomic function during psychological stress. Abstract Text:

Alexander Jones,Alessandro Beda,Alexandra M V Ward,Clive Osmond,David I W Phillips,Vivienne M Moore,David M Simpson,

Small size at birth is associated with exaggerated blood pressure responses to psychological stressors, which increase the risk of developing sustained hypertension in adult life. Explanatory mechanisms for this association are not well characterized. We investigated the hypothesis that an adverse fetal environment, reflected by small size at birth, persistently alters autonomic nervous system and baroreflex control of cardiovascular function, resulting in exaggerated blood pressure and heart rate responses to stressors. Men and women from an Australian prospective cohort study underwent a series of 3 psychological stressors (Stroop, mirror-tracing, and speech) while their blood pressure was recorded continuously using a Portapres. Indices of autonomic function were derived using spectrum analysis (wavelet packet transform), and baroreflex function was estimated using an adaptive autoregressive model. We found that women who were small at birth demonstrated increased levels of low-frequency blood pressure variability at rest (r=-0.28; P<0.05) and during stress (r=-0.42; P<0.001), reduced levels of high-frequency heart period variability (r=0.22; P<0.05), and reduced baroreflex sensitivity (r=0.34; P<0.01). These findings were not present in the men. This study provides evidence that markers of impaired fetal growth are related to autonomic cardiovascular control involving modulation of both sympathetic and parasympathetic function but in a sex-specific manner. We also provide the first human evidence of a relationship between size at birth and baroreflex function.

Size at birth and autonomic function during psychological stress. Publishing Authors By Initials

A Jones,A Beda,AM Ward,C Osmond,DI Phillips,VM Moore,DM Simpson,

For similar behavior and behavior mechanisms: behavior: behavioral symptoms: stress, psychological research abstracts see: behavior and behavior mechanisms: behavior: behavioral symptoms: stress, psychological research

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Size at birth and autonomic function during psychological stress. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Hypertension

VOLUME: 49

Page Numbers: 548-55

Journal Abbreviation: Hypertension

ISSN: 1524-4563

DAY: 22

MONTH: 01

YEAR: 2007

Size at birth and autonomic function during psychological stress. Information

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LANGUAGE: eng

NlmUniqueID: 7906255

Size at birth and autonomic function during psychological stress. Keywords Mesh Terms:

KEYWORDS: Stress, Psychological

MESH TERMS: physiopathology

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Grant and Affiliation Information for Size at birth and autonomic function during psychological stress.

AFFILIATION: Medical Research Council Epidemiology Resource Centre, University of Southampton, Southampton, United Kingdom.

Country: United States

AGENCY: United States NICHD

GRANT: 1 R01 HD41107–01

ACRONYM: HD

MEDLINETA: Hypertension

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