Six-year incidence of proteinuria in type 1 diabetic African Americans.

Six-year incidence of proteinuria in type 1 diabetic African Americans. Research Abstract Details 

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Six-year incidence of proteinuria in type 1 diabetic African Americans. Abstract Text:

Monique S Roy,Mahmoud Affouf,Alec Roy,

OBJECTIVE: We sought to report the 6-year incidence of proteinuria and associated risk factors in African Americans with type 1 diabetes. RESEARCH DESIGN AND METHODS: African Americans (n = 483) with type 1 diabetes were reexamined in a 6-year follow-up study. Proteinuria and creatinuria were measured in 4-h timed urine specimens obtained at initial and follow-up visits. Other evaluations included a structured clinical interview, ocular examination, masked grading of seven stereoscopic fundus photographs, blood pressure measurements, blood assays, and administration of the Beck Depression Inventory (BDI). RESULTS: Over the 6-year period, 117 (42.9%) of the 473 patients at risk developed "any" proteinuria, defined as either microalbuminuria (26.0%) or overt (16.9%) proteinuria; 87 (23.5%) progressed from micro- or no albuminuria to overt proteinuria and 39 (8.7%) to end-stage renal disease; and 40 (20.6%) regressed. Peak incidence of any proteinuria occurred for patients who were 10-14 years of age or had 5-10 years of diabetes duration at baseline. Multiple regression analysis showed that baseline albumin excretion rate (AER), systemic hypertension, blood cholesterol, and high BDI depression scores were significant and independent risk factors for incidence of any proteinuria. CONCLUSIONS: In African Americans with type 1 diabetes, the 6-year incidence of proteinuria is high, particularly among young patients and those with a relatively short duration of diabetes at baseline. Baseline AER is the strongest predictor for incidence of any proteinuria.

Six-year incidence of proteinuria in type 1 diabetic African Americans. Publishing Authors By Initials

MS Roy,M Affouf,A Roy,

For similar investigative techniques: epidemiologic methods: statistics as topic: probability: risk: risk factors research abstracts see: investigative techniques: epidemiologic methods: statistics as topic: probability: risk: risk factors research

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Six-year incidence of proteinuria in type 1 diabetic African Americans. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Diabetes care

VOLUME: 30

Page Numbers: 1807-12

Journal Abbreviation: Diabetes Care

ISSN: 1935-5548

DAY: 2

MONTH: 05

YEAR: 2007

Six-year incidence of proteinuria in type 1 diabetic African Americans. Information

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LANGUAGE: eng

NlmUniqueID: 7805975

Six-year incidence of proteinuria in type 1 diabetic African Americans. Keywords Mesh Terms:

KEYWORDS: Risk Factors

MESH TERMS: etiology

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Grant and Affiliation Information for Six-year incidence of proteinuria in type 1 diabetic African Americans.

AFFILIATION: Institute of Ophthalmology and Visual Science, New Jersey Medical School, University of Medicine and Dentistry, Newark, New Jersey 07101-1709, USA. roymo@umdnj.edu

Country: United States

AGENCY: United States NEI

GRANT: R01 EY 09860

ACRONYM: EY

MEDLINETA: Diabetes Care

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