Site-specific incorporation of a redox-active amino acid into proteins.

Site-specific incorporation of a redox-active amino acid into proteins. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Site-specific incorporation of a redox-active amino acid into proteins. Abstract Text:

Lital Alfonta,Zhiwen Zhang,Sean Uryu,Joseph A Loo,Peter G Schultz,

The redox-active amino acid 3,4-dihydroxy-l-phenylalanine (DHP), which can undergo two-electron oxidation to a quinone, has been incorporated selectively and efficiently into proteins in Escherichia coli in response to a TAG codon. We have demonstrated that DHP can be oxidized electrochemically within the protein. The ability to incorporate a redox-active amino acid site specifically into proteins should facilitate the study of electron transfer in proteins, as well as enable the engineering of redox proteins with novel properties.

Site-specific incorporation of a redox-active amino acid into proteins. Publishing Authors By Initials

L Alfonta,Z Zhang,S Uryu,JA Loo,PG Schultz,

For similar animals: chordata: vertebrates: mammals: cetacea: whales research abstracts see: animals: chordata: vertebrates: mammals: cetacea: whales research

PUBMED ID PMID:

MEDLINE DATE:

Site-specific incorporation of a redox-active amino acid into proteins. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Journal of the American Chemical Society

VOLUME: 125

Page Numbers: 14662-3

Journal Abbreviation: J. Am. Chem. Soc.

ISSN: 0002-7863

DAY: 3

MONTH: Dec

YEAR: 2003

Site-specific incorporation of a redox-active amino acid into proteins. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7503056

Site-specific incorporation of a redox-active amino acid into proteins. Keywords Mesh Terms:

KEYWORDS: Whales

MESH TERMS: metabolism

Chemical & Substance for Abstract: Site-specific incorporation of a redox-active amino acid into proteins. Information

Substance Name: Amino Acyl-tRNA Synthetases

Registry Number: EC 6.1.1.-

Grant and Affiliation Information for Site-specific incorporation of a redox-active amino acid into proteins.

AFFILIATION: Department of Chemistry and the Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

Country: United States

AGENCY: United States NIGMS

GRANT: GM 66494

ACRONYM: GM

MEDLINETA: J Am Chem Soc

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Site-specific incorporation of a redox-active amino acid into proteins Related Publications

• A genetically encoded photocaged tyrosine.
• A phosphoproteomic analysis of the ErbB2 receptor tyrosine kinase signaling pathways.
• Altered Toll-like receptor 9 responses in circulating B cells at the onset of extensive chronic graft-versus-host disease.
• Bovine parthenogenetic blastocysts following in vitro maturation and oocyte activation with ethanol.
• Ca2+ oscillatory pattern in fertilized mouse eggs affects gene expression and development to term.
• Defending the psychiatric malpractice suicide.
• Dose-response relationships in gene expression profiles in rainbow trout, Oncorhyncus mykiss, exposed to ethynylestradiol.
• Dynamics of 17alpha-ethynylestradiol exposure in rainbow trout (Oncorhynchus mykiss): absorption, tissue distribution, and hepatic gene expression pattern.
• From humble beginnings...
• Gene expression patterns in rainbow trout, Oncorhynchus mykiss, exposed to a suite of model toxicants.
• Genetic incorporation of unnatural amino acids into proteins in mammalian cells.
• Global cerebral blood flow in relation to cognitive performance and reserve in subjects with mild memory deficits.
• Glucocorticoids stimulate ENaC upregulation in bovine mammary epithelium.
• History of the international embryo transfer society Part II.
• Implication of nucleolar protein SURF6 in ribosome biogenesis and preimplantation mouse development.
• Incorporation of a follicle stimulating hormone used for embryo transfer in cattle into multilamellar liposomes.
• Modeling the brain-pituitary-gonad axis in salmon.
• Neurodevelopmental and behavioral issues in Williams syndrome.
• Paleohistopathology of bone: A new approach to the study of ancient diseases.
• Recombinant expression of selectively sulfated proteins in Escherichia coli.
• Structural factors influencing linear M-H-M bonding in bis(dialkylphosphino)methane complexes of nickel.
• Synthesis, structure, and properties of low-spin manganese(III)-poly(pyrazolyl)borate complexes.
• Temporal changes in gene expression in rainbow trout exposed to ethynyl estradiol.
• The KAP1 corepressor functions to coordinate the assembly of de novo HP1-demarcated microenvironments of heterochromatin required for KRAB zinc finger protein-mediated transcriptional repression.
• The cardioprotective effect of the low molecular weight isoform of fibroblast growth factor-2: the role of JNK signaling.
• The day of the week when you were born in 700 ms: calendar computation in an Autistic savant.
• The effects of antibodies on stilbene excited-state energetics.
• Thyroid hormone regulates endogenous amyloid-beta precursor protein gene expression and processing in both in vitro and in vivo models.
• Tobacco or health: A global status report.
• Transforming growth factor-beta enhances connective tissue repair in perforated rat mesentery but not peritoneal macrophage chemotaxis.