Site and time dependent effects of acute stress on hippocampal long-term potentiation in freely behaving rats.

Site and time dependent effects of acute stress on hippocampal long-term potentiation in freely behaving rats. Research Abstract Details 

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Site and time dependent effects of acute stress on hippocampal long-term potentiation in freely behaving rats. Abstract Text:

Kazuo Yamada,Bruce S McEwen,Constantine Pavlides,

The phasic effects of stress-induced elevations of corticosterone on long-term potentiation (LTP) were investigated in the hippocampus of awake, freely behaving rats. Field potential recordings were performed in the dentate gyrus with stimulation of the medial perforant pathway or the CA1 with stimulation of the commissural/associational pathway, on the contralateral hemisphere. LTP was induced either shortly (1 h) after acute stress or 4 h later. Animals were either adrenalectomized or adrenally intact. A subgroup of animals were injected with a low dose of dexamethasone 4 h prior to the stressor, in order to suppress the corticosterone response to restraint stress, and they were tested for LTP in the dentate gyrus 4 h after the stressor. In the dentate gyrus, stress had no effect on LTP induction at 1 h post-stress; however, it produced a significant suppression at the 4 h interval. As expected, adrenalectomized rats did not show stress-suppression of LTP, but showed a lower level of LTP with or without stress. Supporting a role of stress-induced glucocorticoid secretion in LTP suppression, dexamethasone treatment of adrenally intact animals blocked the acute stress suppression of LTP in the dentate gyrus. In the CA1 field, restraint stress did not significantly affect LTP induction at either the 1- or 4-h post-stress intervals. Similarly, stress by itself, did not significantly affect neuronal excitability in either the dentate gyrus or CA1 hippocampal field at either the 1- or 4-h post-stress interval. The present results suggest that stress affects synaptic plasticity differently at the two hippocampal subfields and that the effects are time-dependent and involve the stress-induced surge of glucocorticoids.

Site and time dependent effects of acute stress on hippocampal long-term potentiation in freely behaving rats. Publishing Authors By Initials

K Yamada,BS McEwen,C Pavlides,

For similar arousal: wakefulness research abstracts see: arousal: wakefulness research

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Site and time dependent effects of acute stress on hippocampal long-term potentiation in freely behaving rats. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Experimental brain research. Experimentelle Hirnfo

VOLUME: 152

Page Numbers: 52-9

Journal Abbreviation:

ISSN: 0014-4819

DAY: 17

MONTH: 07

YEAR: 2003

Site and time dependent effects of acute stress on hippocampal long-term potentiation in freely behaving rats. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 43312

Site and time dependent effects of acute stress on hippocampal long-term potentiation in freely behaving rats. Keywords Mesh Terms:

KEYWORDS: Wakefulness

MESH TERMS: physiology

Chemical & Substance for Abstract: Site and time dependent effects of acute stress on hippocampal long-term potentiation in freely behaving rats. Information

Substance Name: Dexamethasone

Registry Number: 50-02-2

Grant and Affiliation Information for Site and time dependent effects of acute stress on hippocampal long-term potentiation in freely behaving rats.

AFFILIATION: The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA.

Country: Germany

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MEDLINETA: Exp Brain Res

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