SIRT2 regulates adipocyte differentiation through FoxO1 acetylation/deacetylation.

SIRT2 regulates adipocyte differentiation through FoxO1 acetylation/deacetylation. Research Abstract Details 

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SIRT2 regulates adipocyte differentiation through FoxO1 acetylation/deacetylation. Abstract Text:

Enxuan Jing,Stephane Gesta,C Ronald Kahn,

The family of mammalian Sirtuin proteins comprises seven members homologous to yeast Sir2. Here we show that SIRT2, a cytoplasmic sirtuin, is the most abundant sirtuin in adipocytes. Sirt2 expression is downregulated during preadipocyte differentiation in 3T3-L1 cells. Overexpression of SIRT2 inhibits differentiation, whereas reducing SIRT2 expression promotes adipogenesis. Both effects are accompanied by corresponding changes in the expression of PPARgamma, C/EBPalpha, and genes marking terminal adipocyte differentiation, including Glut4, aP2, and fatty acid synthase. The mechanism underlying the effects of reduced SIRT2 in 3T3-L1 adipocytes includes increased acetylation of FOXO1, with direct interaction between SIRT2 and FOXO1. This interaction enhances insulin-stimulated phosphorylation of FOXO1, which in turn regulates FOXO1 nuclear and cytosolic localization. Thus, Sirt2 acts as an important regulator of adipocyte differentiation through modulation of FOXO1 acetylation/phosphorylation and activity and may play a role in controlling adipose tissue mass and function.

SIRT2 regulates adipocyte differentiation through FoxO1 acetylation/deacetylation. Publishing Authors By Initials

E Jing,S Gesta,CR Kahn,

For similar enzymes and coenzymes: enzymes: hydrolases: amidohydrolases: sirtuins research abstracts see: enzymes and coenzymes: enzymes: hydrolases: amidohydrolases: sirtuins research

PUBMED ID PMID:

MEDLINE DATE:

SIRT2 regulates adipocyte differentiation through FoxO1 acetylation/deacetylation. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Cell metabolism

VOLUME: 6

Page Numbers: 105-14

Journal Abbreviation: Cell Metab.

ISSN: 1550-4131

DAY: 3

MONTH: Aug

YEAR: 2007

SIRT2 regulates adipocyte differentiation through FoxO1 acetylation/deacetylation. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 101233170

SIRT2 regulates adipocyte differentiation through FoxO1 acetylation/deacetylation. Keywords Mesh Terms:

KEYWORDS: Sirtuins

MESH TERMS: metabolism

Chemical & Substance for Abstract: SIRT2 regulates adipocyte differentiation through FoxO1 acetylation/deacetylation. Information

Substance Name: Sirtuins

Registry Number: EC 3.5.1.-

Grant and Affiliation Information for SIRT2 regulates adipocyte differentiation through FoxO1 acetylation/deacetylation.

AFFILIATION: Department of Cellular and Molecular Physiology, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA.

Country: United States

AGENCY: United States NIDDK

GRANT: DK33201

ACRONYM: DK

MEDLINETA: Cell Metab

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