SIRS-associated coagulopathy and organ dysfunction in critically ill patients with thrombocytopenia.

SIRS-associated coagulopathy and organ dysfunction in critically ill patients with thrombocytopenia. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

SIRS-associated coagulopathy and organ dysfunction in critically ill patients with thrombocytopenia. Abstract Text:

Hiroshi Ogura,Satoshi Gando,Toshiaki Iba,Yutaka Eguchi,Yasuhiro Ohtomo,Kohji Okamoto,Kazuhide Koseki,Toshihiko Mayumi,Atsuo Murata,Toshiaki Ikeda,Hiroyasu Ishikura,Masashi Ueyama,Shigeki Kushimoto,Daizoh Saitoh,Shigeatsu Endo,Shuji Shimazaki, ,Hiroshi Ogura,Satoshi Gando,Toshiaki Iba,Yutaka Eguchi,Yasuhiro Ohtomo,Kohji Okamoto,Kazuhide Koseki,Toshihiko Mayumi,Atsuo Murata,Toshiaki Ikeda,Hiroyasu Ishikura,Masashi Ueyama,Shigeki Kushimoto,Daizoh Saitoh,Shigeatsu Endo,Shuji Shimazaki, ,

BACKGROUNDS: Coagulopathy and thrombocytopenia often occur in critically ill patients, and disseminated intravascular coagulation (DIC) can lead to multiple organ dysfunction and a poor outcome. However, the relation between coagulopathy and systemic inflammatory response has not been thoroughly clarified. Thus, we evaluated coagulative activity, organ dysfunction, and systemic inflammatory response syndrome (SIRS) in critically ill patients with thrombocytopenia and examined the balance between coagulopathy and systemic inflammation. PATIENTS AND METHODS: Two hundred seventy-three patients, who were admitted to 13 critical care centers in Japan and fulfilled the criteria of platelet count of less than 150*10(9)/L, were included. Coagulative variables (platelet count, fibrin/fibrinogen degradation products, and DIC scores), organ dysfunction index (Sequential Organ Failure Assessment [SOFA] score), and SIRS score in each patient were evaluated for 4 consecutive days after fulfilling the above entry criteria. The effect of SIRS on coagulopathy and organ dysfunction was evaluated in these patients. RESULTS: Both the maximum SIRS score and entry SIRS score had significant relation to the maximum SOFA score during the observation period. Coagulation disorders indicated by the minimum platelet count, maximum DIC scores, and positivity for DIC worsened gradually with increases in SIRS scores. Both the minimum platelet count and maximum DIC scores were significantly correlated with the maximum SOFA score, indicating that a relation exists between coagulopathy and organ dysfunction. CONCLUSIONS: In critically ill patients with thrombocytopenia, coagulopathy and organ dysfunction progress with significant mutual correlation, depending on the increase in SIRS scores. The SIRS-associated coagulopathy may play a critical role in inducing organ dysfunction after severe insult.

SIRS-associated coagulopathy and organ dysfunction in critically ill patients with thrombocytopenia. Publishing Authors By Initials

H Ogura,S Gando,T Iba,Y Eguchi,Y Ohtomo,K Okamoto,K Koseki,T Mayumi,A Murata,T Ikeda,H Ishikura,M Ueyama,S Kushimoto,D Saitoh,S Endo,S Shimazaki, ,H Ogura,S Gando,T Iba,Y Eguchi,Y Ohtomo,K Okamoto,K Koseki,T Mayumi,A Murata,T Ikeda,H Ishikura,M Ueyama,S Kushimoto,D Saitoh,S Endo,S Shimazaki, ,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

SIRS-associated coagulopathy and organ dysfunction in critically ill patients with thrombocytopenia. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Shock (Augusta, Ga.)

VOLUME: 28

Page Numbers: 411-7

Journal Abbreviation: Shock

ISSN: 1073-2322

DAY: 12

MONTH: Oct

YEAR: 2007

SIRS-associated coagulopathy and organ dysfunction in critically ill patients with thrombocytopenia. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9421564

SIRS-associated coagulopathy and organ dysfunction in critically ill patients with thrombocytopenia. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: SIRS-associated coagulopathy and organ dysfunction in critically ill patients with thrombocytopenia. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for SIRS-associated coagulopathy and organ dysfunction in critically ill patients with thrombocytopenia.

AFFILIATION: Department of Traumatology and Acute Critical Medicine, Osaka University Medical School, Suita, Japan. ogura@hp-emerg.med.osaka-u.ac.jp

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Shock

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

SIRS-associated coagulopathy and organ dysfunction in critically ill patients with thrombocytopenia Related Publications

• Achievements and future problems with component surgery of the cornea.
• Amniotic membrane transplantation for wound dehiscence after deep lamellar keratoplasty: a case report.
• Barrier function and cytologic features of the ocular surface epithelium after autologous cultivated oral mucosal epithelial transplantation.
• Blue light-induced autophosphorylation of phototropin is a primary step for signaling.
• Hyperleukocytosis in patients with leukemic follicular lymphoma.
• Immunohistochemistry and electron microscopy of retrocorneal scrolls in syphilitic interstitial keratitis.
• In vitro effects of bovine lactoferrin on autoaggregation ability and surface hydrophobicity of bifidobacteria.
• Insects from the grazing food web favoured the evolutionary habitat shift to bright environments in araneoid spiders.
• Interrelationship between plasma ionized calcium, plasma noradrenaline (NA) and pressor response to infused NA in patients with essential hypertension.
• Metastasis suppressor genes for prostate cancer.
• Nonsurgical management of patients with blunt hepatic injury: efficacy of transcatheter arterial embolization.
• Nonsurgical management of patients with blunt splenic injury: efficacy of transcatheter arterial embolization.
• Outcome of patients with hormone-refractory prostate cancer: prognostic significance of prostate-specific antigen-doubling time and nadir prostate-specific antigen.
• Physiological properties of projection neurons in the monkey striatum to the globus pallidus.
• Postkeratoplasty atopic sclerokeratitis in keratoconus patients.
• Predicting the severity of systemic inflammatory response syndrome (SIRS)-associated coagulopathy with hemostatic molecular markers and vascular endothelial injury markers.
• Prop-type damping device.
• Protein phosphorylation and binding of a 14-3-3 protein in Vicia guard cells in response to ABA.
• SIRS-associated coagulopathy and organ dysfunction in critically ill patients with thrombocytopenia.
• Sensory afferent properties of immobilised or inflamed rat knees during continuous passive movement.
• Thyroid storm after blunt thyroid injury: a case report.
• [A case of caffeine poisoning, survived by percutaneous cardio-pulmonary support]
• [Focal point in the evaluation of nursing fees. A discussion]
• [Multiple coronary aneurysm resulting in myocardial infarction in a young man - successful surgical treatment using a bypass graft]
• [Nursing report: nursing students; attitudes toward nursing at the time of graduation from a 3-year nursing college]
• [Personification; a psychopathological study of the feeling of nature.]
• [Radiation induced osteosarcoma of the chest wall]
• [Simultaneous repair for funnel chest and intracardiac lesions in two pediatric patients]
• [The role of stem cell transplantation for multiple myeloma]
• [Ventricular volume characteristics and function in patients with single ventricle]