Sintering, crystallisation and biodegradation behaviour of Bioglass-derived glass-ceramics.

Sintering, crystallisation and biodegradation behaviour of Bioglass-derived glass-ceramics. Research Abstract Details 

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Sintering, crystallisation and biodegradation behaviour of Bioglass-derived glass-ceramics. Abstract Text:

Aldo R Boccaccini,Qizhi Chen,Leila Lefebvre,Laurent Gremillard, Chevalier,

Sintering and crystallisation phenomena in powders of a typical bioactive glass composition (45S5 Bioglass) have been investigated in order to gain further understanding of the processes involved in the fabrication of Bioglass, based glass-ceramic scaffolds for tissue engineering applications. In situ experiments in an environmental scanning electron microscope with a heating stage were carried out to follow the morphology of Bioglass particles during sintering and crystallisation. Optimal processing parameters for the manufacture of Bioglass based glass-ceramic scaffolds by the foam-replica technique were determined. To assess the in vitro performance and bioreactivity of Bioglass -derived glass-ceramic scaffolds, the biodegradation of samples in simulated body fluid (SBF) was investigated using various techniques, including SEM, TEM, XRD and EDX. The mechanism of interaction of the glass-ceramic surface with SBF was determined, which involves (i) preferential dissolution at glass/crystal interfaces, (ii) break-down of crystalline particles into very fine grains through preferential dissolution at crystal structural defects, and (iii) amorphisation of the crystalline structure by introduction of point defects produced during ion exchange. The present report thus offers for the first time a complete assessment of the processing parameters, microstructure, and in vitro performance of Bioglass derived glass-ceramic scaffolds intended for bone tissue engineering.

Sintering, crystallisation and biodegradation behaviour of Bioglass-derived glass-ceramics. Publishing Authors By Initials

AR Boccaccini,Q Chen,L Lefebvre,L Gremillard,J Chevalier,

For similar investigative techniques: clinical laboratory techniques: culture techniques: tissue engineering research abstracts see: investigative techniques: clinical laboratory techniques: culture techniques: tissue engineering research

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Sintering, crystallisation and biodegradation behaviour of Bioglass-derived glass-ceramics. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Faraday discussions

VOLUME: 136

Page Numbers: 27-44; discussion 107-23

Journal Abbreviation: Faraday Discuss.

ISSN: 1359-6640

DAY: 28

MONTH: 11

YEAR: 2007

Sintering, crystallisation and biodegradation behaviour of Bioglass-derived glass-ceramics. Information

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LANGUAGE: eng

NlmUniqueID: 9212301

Sintering, crystallisation and biodegradation behaviour of Bioglass-derived glass-ceramics. Keywords Mesh Terms:

KEYWORDS: Tissue Engineering

MESH TERMS: metabolism

Chemical & Substance for Abstract: Sintering, crystallisation and biodegradation behaviour of Bioglass-derived glass-ceramics. Information

Substance Name: Ceramics

Registry Number: 0

Grant and Affiliation Information for Sintering, crystallisation and biodegradation behaviour of Bioglass-derived glass-ceramics.

AFFILIATION: Department of Materials, Imperial College London, Prince Consort Road, London, UK SW7 2BP.

Country: England

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MEDLINETA: Faraday Discuss

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