Single photon emission computed tomography perfusion differences in mild cognitive impairment.

Single photon emission computed tomography perfusion differences in mild cognitive impairment. Research Abstract Details 

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Single photon emission computed tomography perfusion differences in mild cognitive impairment. Abstract Text:

K A Johnson,E K Moran,J A Becker,D Blacker,A J Fischman,M S Albert,

OBJECTIVE: To relate cerebral perfusion abnormalities to subsequent changes in clinical status among patients with mild cognitive impairment (MCI). METHODS: Perfusion single photon emission computed tomography (SPECT) images were acquired in 105 elderly patients without dementia with MCI, using 99mTc-HMPAO. Clinical outcome after a 5-year follow-up period was heterogeneous. RESULTS: Baseline SPECT data differed in those patients with MCI who were later diagnosed with Alzheimer's disease (the converter group) from those patients with MCI who experienced clinically evident decline but did not progress to a diagnosis of Alzheimer's disease within the follow-up period (the decliner group), from patients with MCI who had no clinical evidence of progression (the stable group), and from a group of 19 normal subjects (the control group). The most consistent decreases in relative perfusion in converters compared with the normal, stable and decliner groups were observed in the caudal anterior cingulate, and in the posterior cingulate. In addition, converters showed increased relative perfusion in the rostral anterior cingulate in comparison to the stable and decliner groups. A group of patients with Alzheimer's disease were also included for purposes of comparison. The group of patients with Alzheimer's disease at baseline differed from each of the other groups, with temporoparietal regions showing the most significant reductions in perfusion. CONCLUSIONS: These results suggest that clinical heterogeneity in MCI is reflected in SPECT perfusion differences, and that the pattern of perfusion abnormalities evolves with increasing clinical severity.

Single photon emission computed tomography perfusion differences in mild cognitive impairment. Publishing Authors By Initials

KA Johnson,EK Moran,JA Becker,D Blacker,AJ Fischman,MS Albert,

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Single photon emission computed tomography perfusion differences in mild cognitive impairment. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of neurology, neurosurgery, and psychiatry

VOLUME: 78

Page Numbers: 240-7

Journal Abbreviation: J. Neurol. Neurosurg. Psychiat

ISSN: 1468-330X

DAY: 20

MONTH: 10

YEAR: 2006

Single photon emission computed tomography perfusion differences in mild cognitive impairment. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 2985191

Single photon emission computed tomography perfusion differences in mild cognitive impairment. Keywords Mesh Terms:

KEYWORDS: Tomography, Emission-Computed, Single-Ph

MESH TERMS: diagnostic use

Chemical & Substance for Abstract: Single photon emission computed tomography perfusion differences in mild cognitive impairment. Information

Substance Name: Technetium Tc 99m Exametazime

Registry Number: 100504-35-6

Grant and Affiliation Information for Single photon emission computed tomography perfusion differences in mild cognitive impairment.

AFFILIATION: Department of Radiology, Massachusetts General Hospital, Fruit Street, Boston, MA 02114, USA. kajohnson@partners.org

Country: England

AGENCY: United States NIA

GRANT: P01-AG04953

ACRONYM: AG

MEDLINETA: J Neurol Neurosurg Psychiatry

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