Single photon emission computed tomography and positron emission tomography imaging of multi-drug resistant P-glycoprotein--monitoring a transport activity important in cancer, blood-brain barrier function and Alzheimer's disease.

Single photon emission computed tomography and positron emission tomography imaging of multi-drug resistant P-glycoprotein--monitoring a transport activity important in cancer, blood-brain barrier function and Alzheimer's disease. Research Abstract Details 

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Single photon emission computed tomography and positron emission tomography imaging of multi-drug resistant P-glycoprotein--monitoring a transport activity important in cancer, blood-brain barrier function and Alzheimer's disease. Abstract Text:

David Piwnica-Worms,Aparna H Kesarwala,Andrea Pichler,Julie L Prior,Vijay Sharma,

Overexpression of multi-drug resistant P-glycoprotein (Pgp) remains an important barrier to successful chemotherapy in cancer patients and impacts the pharmacokinetics of many important drugs. Pgp is also expressed on the luminal surface of brain capillary endothelial cells wherein Pgp functionally comprises a major component of the blood-brain barrier by limiting central nervous system penetration of various therapeutic agents. In addition, Pgp in brain capillary endothelial cells removes amyloid-beta from the brain. Several single photon emission computed tomography and positron emission tomography radiopharmaceutical have been shown to be transported by Pgp, thereby enabling the noninvasive interrogation of Pgp-mediated transport activity in vivo. Therefore, molecular imaging of Pgp activity may enable noninvasive dynamic monitoring of multi-drug resistance in cancer, guide therapeutic choices in cancer chemotherapy, and identify transporter deficiencies of the blood-brain barrier in Alzheimer's disease.

Single photon emission computed tomography and positron emission tomography imaging of multi-drug resistant P-glycoprotein--monitoring a transport activity important in cancer, blood-brain barrier function and Alzheimer's disease. Publishing Authors By Initials

D Piwnica-Worms,AH Kesarwala,A Pichler,JL Prior,V Sharma,

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PUBMED ID PMID:

MEDLINE DATE:

Single photon emission computed tomography and positron emission tomography imaging of multi-drug resistant P-glycoprotein--monitoring a transport activity important in cancer, blood-brain barrier function and Alzheimer's disease. Journal Published:

PUBLICATION TYPE: Review

Journal: Neuroimaging clinics of North America

VOLUME: 16

Page Numbers: 575-89, viii

Journal Abbreviation: Neuroimaging Clin. N. Am.

ISSN: 1052-5149

DAY: 3

MONTH: Nov

YEAR: 2006

Single photon emission computed tomography and positron emission tomography imaging of multi-drug resistant P-glycoprotein--monitoring a transport activity important in cancer, blood-brain barrier function and Alzheimer's disease. Information

Number of References: 144

LANGUAGE: eng

NlmUniqueID: 9211377

Single photon emission computed tomography and positron emission tomography imaging of multi-drug resistant P-glycoprotein--monitoring a transport activity important in cancer, blood-brain barrier function and Alzheimer's disease. Keywords Mesh Terms:

KEYWORDS: Tomography, Emission-Computed, Single-Ph

MESH TERMS: diagnostic use

Chemical & Substance for Abstract: Single photon emission computed tomography and positron emission tomography imaging of multi-drug resistant P-glycoprotein--monitoring a transport activity important in cancer, blood-brain barrier function and Alzheimer's disease. Information

Substance Name: Nimodipine

Registry Number: 66085-59-4

Grant and Affiliation Information for Single photon emission computed tomography and positron emission tomography imaging of multi-drug resistant P-glycoprotein--monitoring a transport activity important in cancer, blood-brain barrier function and Alzheimer's disease.

AFFILIATION: Washington University Medical School, 510 South Kingshighway Boulevard, Box 8225, St. Louis, MO 63110, USA. piwnica-wormsd@mir.wustl.edu

Country: United States

AGENCY: United States NCI

GRANT: P50 CA94056

ACRONYM: CA

MEDLINETA: Neuroimaging Clin N Am

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