Single neurons in the nucleus of the solitary tract respond selectively to bitter taste stimuli.

Single neurons in the nucleus of the solitary tract respond selectively to bitter taste stimuli. Research Abstract Details 

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Single neurons in the nucleus of the solitary tract respond selectively to bitter taste stimuli. Abstract Text:

Laura C Geran,Susan P Travers,

Molecular data suggest that receptors for all bitter ligands are coexpressed in the same taste receptor cells (TRCs), whereas physiological results indicate that individual TRCs respond to only a subset of bitter stimuli. It is also unclear to what extent bitter-responsive neurons are stimulated by nonbitter stimuli. To explore these issues, single neuron responses were recorded from the rat nucleus of the solitary tract (NST) during whole mouth stimulation with a variety of bitter compounds: 10 microM cycloheximide, 7 mM propylthiouracil, 10 mM denatonium benzoate, and 3 mM quinine hydrochloride at intensities matched for behavioral effectiveness. Stimuli representing the remaining putative taste qualities were also tested. Particular emphasis was given to activating taste receptors in the foliate papillae innervated by the quinine-sensitive glossopharyngeal nerve. This method revealed a novel population of bitter-best (B-best) cells with foliate receptive fields and significant selectivity for bitter tastants. Across all neurons, multidimensional scaling depicted bitter stimuli as loosely clustered yet clearly distinct from nonbitter tastants. When neurons with posterior receptive fields were analyzed alone, bitter stimuli formed a tighter cluster. Nevertheless, responses to bitter stimuli were variable across B-best neurons, with cycloheximide the most, and quinine the least frequent optimal stimulus. These results indicate heterogeneity for the processing of ionic and nonionic bitter tastants, which is dependent on receptive field. Further, they suggest that neurons selective for bitter substances could contribute to taste coding.

Single neurons in the nucleus of the solitary tract respond selectively to bitter taste stimuli. Publishing Authors By Initials

LC Geran,SP Travers,

For similar sensation: taste research abstracts see: sensation: taste research

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MEDLINE DATE:

Single neurons in the nucleus of the solitary tract respond selectively to bitter taste stimuli. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Journal of neurophysiology

VOLUME: 96

Page Numbers: 2513-27

Journal Abbreviation: J. Neurophysiol.

ISSN: 0022-3077

DAY: 9

MONTH: 08

YEAR: 2006

Single neurons in the nucleus of the solitary tract respond selectively to bitter taste stimuli. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 375404

Single neurons in the nucleus of the solitary tract respond selectively to bitter taste stimuli. Keywords Mesh Terms:

KEYWORDS: Taste

MESH TERMS: physiology

Chemical & Substance for Abstract: Single neurons in the nucleus of the solitary tract respond selectively to bitter taste stimuli. Information

Substance Name: Quinine

Registry Number: 130-95-0

Grant and Affiliation Information for Single neurons in the nucleus of the solitary tract respond selectively to bitter taste stimuli.

AFFILIATION: Section of Oral Biology, College of Dentistry, Ohio State University, 305 W. 12th Ave. Postle Hall, Columbus, OH 43210, USA.

Country: United States

AGENCY: United States NIDCR

GRANT: T32-DE-014320

ACRONYM: DE

MEDLINETA: J Neurophysiol

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