Single-dosage pharmacokinetics of sodium ferric gluconate complex in iron-deficient pediatric hemodialysis patients.

Single-dosage pharmacokinetics of sodium ferric gluconate complex in iron-deficient pediatric hemodialysis patients. Research Abstract Details 

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Single-dosage pharmacokinetics of sodium ferric gluconate complex in iron-deficient pediatric hemodialysis patients. Abstract Text:

Bradley A Warady,Paul A Seligman,Naomi V Dahl,

BACKGROUND AND OBJECTIVES: The clinical use of sodium ferric gluconate complex in iron-deficient pediatric patients receiving hemodialysis was recently approved. This study was designed to describe the pharmacokinetic parameters of the medication. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Iron-deficient pediatric (< or = 15 yr) hemodialysis patients were randomly assigned to two doses (1.5 and 3.0 mg/kg) of sodium ferric gluconate complex. Blood samples taken during a 1-h infusion and at multiple intervals during 48 h were analyzed for total iron, transferrin-bound iron, and sodium ferric gluconate complex-bound iron. RESULTS: Forty-nine patients (mean age 12.3 +/- 2.5 yr) participated in the study. Mean serum iron concentrations rapidly increased in a dosage-dependent manner. A rapid rise in total serum iron was followed by a slower, less prominent rise in transferrin-bound iron. This was qualitatively confirmed by visualization of the transferrin bands from polyacrylamide gel electrophoresis. Single-dose pharmacokinetics of sodium ferric gluconate complex-bound iron was described using noncompartmental analytical methods. Mean values for the 1.5 mg/Kg dose were as follows: t(1/2) 2.0 +/- 0.7 h, Cmax 1287 mcg/dl, Tmax 1.1 +/- 0.23 h, Cl 0.69 +/- 0.50 L/h, Vd 1.6 +/- 0.6 L, AUC(0-infinity). 9499 +/- 4089 mcg x hr/dl. CONCLUSIONS: The infusion of sodium ferric gluconate complex to pediatric patients who receive hemodialysis appears to result in a delayed transfer of iron to transferrin, likely after an initial movement through the reticuloendothelial system. Differences noted between the pediatric and adult pharmacokinetic data may result from the unique aspects of the study populations and the respective study designs.

Single-dosage pharmacokinetics of sodium ferric gluconate complex in iron-deficient pediatric hemodialysis patients. Publishing Authors By Initials

BA Warady,PA Seligman,NV Dahl,

For similar proteins: blood proteins: acute-phase proteins: transferrin research abstracts see: proteins: blood proteins: acute-phase proteins: transferrin research

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Single-dosage pharmacokinetics of sodium ferric gluconate complex in iron-deficient pediatric hemodialysis patients. Journal Published:

PUBLICATION TYPE: Randomized Controlled Trial

Journal: Clinical journal of the American Society of Nephro

VOLUME: 2

Page Numbers: 1140-6

Journal Abbreviation:

ISSN: 1555-905X

DAY: 17

MONTH: 10

YEAR: 2007

Single-dosage pharmacokinetics of sodium ferric gluconate complex in iron-deficient pediatric hemodialysis patients. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 101271570

Single-dosage pharmacokinetics of sodium ferric gluconate complex in iron-deficient pediatric hemodialysis patients. Keywords Mesh Terms:

KEYWORDS: Transferrin

MESH TERMS: metabolism

Chemical & Substance for Abstract: Single-dosage pharmacokinetics of sodium ferric gluconate complex in iron-deficient pediatric hemodialysis patients. Information

Substance Name: ferric gluconate

Registry Number: 88088-23-7

Grant and Affiliation Information for Single-dosage pharmacokinetics of sodium ferric gluconate complex in iron-deficient pediatric hemodialysis patients.

AFFILIATION: Department of Pediatrics, Section of Pediatric Nephrology, Children's Mercy Hospital, 2401 Gillham Road, Kansas City, MO 64108, USA. bwarady@cmh.edu

Country: United States

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MEDLINETA: Clin J Am Soc Nephrol

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